Welcome to our current edition of Pulmonary Pathology Reviews, a multi-institutional journal cub intended to keep all of those with an interest in diagnostic pulmonary pathology on the same page when it comes to the fast paced world of relevant peer-reviewed publications. This month's journal club reviews articles that appeared in the print literature in March 2017 and comes to us courtesy of Jenn Boland at Mayo Clinic Minnesota and their fully engaged thoracic pathology fellow, Roger Hsu. Click here for a PDF summary of the articles reviewed, a summary intended to cover the highlights and save you the trouble of having to read the articles for yourself! What follows is their OVERVIEW summarizing what's hot and what's not. An ARTICLE INDEX provides links to PubMed abstracts and full text versions if your institution is appropriately licensed for access. And if you want to listen to the teleconference exactly as it unfolded on Monday morning at 08:15 CDT click here to download an MP3 audiofile (and be patient . . . depending on bandwidth can take awhile to download).
Some great articles to discuss from March 2017, in the areas of both neoplastic and non-neoplastic lung pathology. The first article will be discussed by our current pulmonary pathology fellow, Dr. Roger Hsu. He will cover an article from JTO by Luo et al, which uses digital computational analysis of scanned histologic slides. They found several “texture-related” features associated with outcome in pulmonary adenocarcinoma, and “granularity-related” features associated with outcome in squamous cell carcinoma. Next, I will try to get through 4 interesting papers in the time allotted. The first is from Kelly Butnor from our Journal Club Group, along with her group of collaborators. They describe Crohns disease as a risk factor for peritoneal mesothelioma in their article featured in the Journal of Clinical Pathology. The second paper I have chosen is from Kroner et al in Thorax, which describes the spectrum of lung disease observed in ABCA3 mutations. This gene encodes a protein important in surfactant production. While most of this lung disease occurs in infants and young children, they observed several older children, teenagers, and adults first presenting with fibrotic interstitial lung disease, so I think it is a topic worth knowing about. The token PDL1 paper this month is from Rehman et al in Modern Pathology, which compared digital reads using quantitative immunofluorescence to pathologists’ manual readings. They also look at interobserver agreement in interpreting tumor cell and immune cell staining. And finally, the last paper was published in Histopathology by Kojima et al. They describe a cohort of lung cancers arising in a background of idiopathic interstitial pneumonia, with a special emphasis on adenocarcinoma.
Articles for Discussion
Luo X, X Zhang, L Yang, J Huang, et al. Comprehensive Computational Pathological Image Analysis Predicts Lung Cancer Prognosis. J Thorac Oncol 2017;12(3):501-509.
Butnor KJ, EN Pavlisko, TA Sporn, VL Roggli. Malignant Peritoneal Mesothelioma and Crohns Disease. J Clin Pathol 2017; 70:228-232.
Kroner C, T Wittman, S Reu, V Teusch, et al. Lung Disease Caused by ABCA3 mutations. Thorax 2017; 72:213-220.
Rehman JA, G Han, DE Carvajal-Hausdorf, BE Wasserman, et al. Quantitative and Pathologist-Read Comparison of the Heterogeneity of Programmed Death Ligand-1 (PDL-1) Expression in Non-Small Cell Lung Cancer. Modern Pathol 2017;30:340-349.
Kojima Y, K Okudela, M Matsumura, T Omori, et al. The Pathological Features of Idiopathic Interstitial Pneumonia-Associated Pulmonary Adenocarcinomas. Histopathol 2017;70:568-578.
Articles for Notation
Coroller TP, V Agrawal, E Huynh, V Narayan, et al. Radiomic-based Pathological Response Prediction from Primary Tumors and Lymph Nodes in NSCLC. J Thorac Oncol 2017;12(3):467-476.
de Parrot M, Z Dong, P Bradbury, D Patsios, et al. Impact of Tumor Thickness on Survival after Radical Radiation and Surgery in Malignant Pleural Mesothelioma. Eur Respir J 2017;49:1601428.
Gachechiladze M, J Skarda, V Kolek, I Grygarkova, et al. Prognostic and Predictive Value of Nuclear RAD51 Immunoreactivity in Non-Small Cell Lung Cancer Patients. Lung Cancer 2017;105:31-38.
Hubers AJ, DAM Heideman, S Duin, BI Witte, et al. DNA Hypermethylation Analysis in Sputum of Asymptomatic Subjects at Risk for Lung Cancer Participating in the NELSON Trial: Argument for Maximal Screening Interval of 2 Years. J Clin Pathol 2017;70:250-54.
Lepere C, A Cortot, V Gragoire, V Cockenpot, et al. Preferential Localization of MET Expression at the Invasion Front and in Spreading Cells Through Alveolar Spaces in Non-Small Cell Lung Carcinomas. Am J Surg Pathol 2017;41(3):414-22.
Nicholson A, F Detterbeck, A Marx, AC Roden, et al. Dataset for the Reporting of Thymic Epithelial Tumours: Recommendations from the International Collaboration on Cancer Reporting (ICCR). Histopathol 2017;70:522-35.
Ou SHI, A Schrock, EV Bocharov, SJ Klempner, et al. Her2 Transmembrane Domain (TMD) Mutations (V659/G660) that Stabilize Homo- and Heterodimerization are Rare Oncogenic Drivers in Lung Adenocarcinomas that Respond to Afatinib. J Thorac Oncol 2017;12(3):446-57.
Padmanabhan V, HB Steinmetz, EJ Rizzo, AJ Erskine, et al. Improving Adequacy of Small Biopsy and Fine Needle Aspiration Specimens for Molecular Testing by Next-Generation Sequencing in Patients with Lung Cancer. Archives Lab Med Pathol 2017;141:402-409.
Shin J, B Keam, M Kim, YS Park, et al. Prognostic Impact of Newly Proposed M Descriptors in TNM Classification of Non-Small Cell Lung Cancer. J Thorac Oncol 2017;12(3):520-28.
Soo RA, HR Kim, BR Asuncion, Z Fazreen, et al. Significance of Immune Checkpoint Proteins in EGFR-mutant Non-Small Cell Lung Cancer. Lung Cancer 2017;105:17-22.
Uruga H, E Bozkurtlar, TG Huynh, A Muzikansky, et al. Programed Cell Death Ligand-1 (PD-L1) Expression in Stage II and III Lung Adenocarcinomas and Nodal Metastases. J Thorac Oncol 2017;12(3):458-466.
Woody NM, KL Stephans, M Andrews, T Zhuang, et al. A Histologic Basis for the Efficacy of SBRT to the Lung. J Thorac Oncol 2017:12(3):510-519.
Zhao Y, G Li, D Zheng, M Jia, et al. The Prognostic Value of Lymph Node Ratio and Log Odds of Positive Lymph Nodes in Patients with Lung Adenocarcinoma. J Thorac Cardiovasc Surg 2017;153(3):702-709.
Mercier O, JA Ataam, NB Langer, P Dorfmuller, et al. Abnormal Pulmonary Endothelial Cells may Underlie the Enigmatic Pathogenesis of Chronic Thromboembolic Pulmonary Hypertension. J Heart Lung Transplant 2017;36(3):305-14.
Reviews, Editorials, Letters, etc
Burge PS, J Reynolds, S Trotter, GA Burge, et al. Histologists’ Original Opinion Compared with Multidisciplinary Team in Determining Diagnosis in Interstitial Lung Disease. Thorax 2017;72(3):280-81.
Cao L, J Xu. Integrin β4 is a Controversial Target for Non-Small Cell Lung Cancer. Human Pathol 2017;61:222.
Stewart RL, KL O’Conner. Integrin β4 is a Controversial Target for Non-Small Cell Lung Cancer-Reply. Human Pathol 2017;61:223-4.
Chui K and JL Wright. Large and Small Airway Disease Related to Inflammatory Bowel Disease. Arch Lab Med Pathol 2017;141:470-73.
Dautzenberg B, and D Garelik. Patents with Lung Cancer: Are Electronic Cigarettes Harmful of Useful? Lung Cancer 2017;105:42-48.
Hendifar AE, AM Marchevsky, R Tuli. Neuroendocrine Tumors of the Lung: Current Challenges and Advancements in the Diagnosis and Management of Well-Differentiated Disease. J Thorac Oncol 2017;12(3):425-36.
Maldonado F. Are Transbronchial Biopsies Living up to the Expectations? Chest 2017;151(3):722.
Mao R and K Fei. The Clinical Implications and Thoughts on Different Patterns in Resected Lung Adenocarcinoma. . J Thorac Oncol 2017;12(3):e24-25.
Yanagawa N. The Clinical Implications and Thoughts on Different Patterns in Resected Lung Adenocarcinoma. . J Thorac Oncol 2017;12(3):e25-26.
Ussavarungsi K, ES Edell, and JH Ryu. Are Transbronchial Biopsies Living up to the Expectations?-Response. Chest 2017;151(3):722-23.
Notsuda H, PA Bradbury, MS Tsao. Her2 Transmembrane Domain Mutations: Rare New Target for Non-Small Cell Lung Cancer Therapy. J Thorac Oncol 2017;12(3):422-24.
Sun PL, H Sasano, and H Gao. BCL-2 Family in Non-Small Cell Lung Cancer: Its Prognostic and Therapeutic Implications. Pathol International 2017;67:121-130.
Upham JW and Y Xi. Dendritic Cells in Human Lung Disease. Chest 2017;151(3):668-673.
Zugazagoitia J, S Molina-Pinelo, F Lopez-Rios, and L Paz-Ares. Biological Therapies in Non-Small Cell Lung Cancer. Eur Respir J 2017;49:1601520.
Brustle K, S Lema, P Komminoth, W Weder, et al. Placental transmogrification of the Lung Presenting as Progressive Symptomatic Bullous Emphysema. Thorax 2017;72:284-85.
Jin Y, X Shen, L Shen, Y Sun, et al. Ciliated Muconodular Papillary Tumor of the Lung Harboring ALK Gene Rearrangement: Case Report and Review of the Literature. Pathol International 2017;67:171-175.
Le T, J Sailors, DH Oliver, M Mayer, et al. Histologic Transformation of EGFR Mutant Lung Adenocarcinoma without Exposure to EGFR Inhibition. Lung Cancer 2017;105:14-16.
Ong PG, RF Casal, J Stewart, GA Eapen, et al. Metastatic Cancer Mimicking a Mycetoma. Am J Resp Critical Care Med 2017;195:e29-e30.