Welcome to the latest edition of Pulmonary Pathology Reviews, a monthly multi-institutional journal club in which one of several participating faculty summarizes what's hot and what's not in papers relevant to pulmonary pathology that appeared in the peer-reviewed print literature in the preceding month. This month comes to us from the University of Michigan famous not only for its basketball but also Lindsay Schmidt, Assistant Professor of Pathology. Check out her OVERVIEW below for a thumbnail of articles that she highlighted from March journals. If you want the CribNotes version of the articles themselves click here to get her article summaries as a PDF file. Lindsay's OVERVIEW is followed by an ARTICLE INDEX that includes links to PubMed abstracts (and full text versions if your institution allows it) for all included articles. And if you want to hear how it all went down in our teleconference at 09:15 EDT on Monday, April 29th, click here.
I found 18 articles in our journals this month that I felt would be of interest to the group. As is the norm, most are neoplastic, but there are some interesting nonneoplastic articles as well, focusing on some esoteric topics that don't often get a lot of press. The three discussion articles this month all come from the neoplastic side of things.
The first article for discussion (Grogg KL et al.) comes from the Mayo group, and is a very interesting look at nodular pulmonary amyloidosis. This unusual entity is something I'm sure we all get to see from time to time, and this paper did an excellent and very thorough job of immunophenotyping a good set of these tumors.
The second paper (Doxtader EE et al.) comes from the SUNY group, and is my favorite kind of study--one based on H&E! This group looked at the biopsy site changes introduced into lung cancers through needle biopsies, and presented the interesting differential diagnosis of desmoplastic stroma. A good topic to review in light of the proposed reclassification of lung tumors.
The last article for discussion (Sholl LM et al.) is yet another look at ALK translocations. In this case, it is a comparison of FISH and immunohistochemistry that makes the case for using BOTH methods instead of one versus the other.
For notation, there are 10 additional neoplastic disease articles. Cho et al. present data on using tumor markers performed on aspirate fluid in diagnosing nonsmall cell lung carcinoma. A second ALK article this month (Conde et al) presents the rates of ALK translocation-associated lung adenocarcinomas seen at one intitution. In an article in the New England Journal, Friboulet et al. take an interesting look at a previously described marker, ERCC1, and its implications in chemotherapeutic response. Two groups (Ishii et al. and Kadota et al.) present different immunohistochemical markers as prognostic factors in small cell lung cancer and adenocarcinoma respectively. Another prognostic paper, Liu et al. describe the prognostic factors in N1-stage II NSCLC. For the economists in the group, an Australian group (Steinfort et al.) take a look at the economic impact of method of biopsy (transbronchial versus needle) in a very hypothetical way. There are two mesothelioma articles this month: Ordonez describes the histologic, immunohistochemical, and ultrastructural findings in signet-ring cell mesothelioma, and Lee et al. describe several more IHC markers attempting to distinguish benign from malignant mesotheliomas. Lastly, William et al. publish an excellent review of lymphoproliferative neoplasms on the lung in Archives.
Five nonneoplastic articles were included for notation. Three focused on transplant patients: DeNicola et al. describe the findings in patients with anti-HLA antibodies, a topic we have discussed in this group before, and Ofek et al. describe the pathologic findings of restrictive allograft syndrome. The last, Yarmus et al., describe a newer technique being used to perform transbronchial biopsies to evaluate lung allograft rejection. Nakajima et al. present the pathologic findings of H5N1 influenza, and Furuya et al. describe the pulmonary features of Birt-Hogg-Dube syndrome and how to distinguish it from other cystic lung disease.
Grogg KL et al. "Nodular pulmonary amyloidosis is characterized by localized immunoglobulin deposition and is frequently associated with an indolent B-cell lymphoproliferative disorder." Am J Surg Pathol 37: 406-412.
Doxtader EE et al. "Biopsy-site changes in lung adenocarcinoma with prior core needle biopsy: a potential pitfall in the assessment of stromal invasion." Am J Surg Pathol 37: 443-446.
Sholl LM et al. "Combined use of ALK immunohistochemistry and FISH for optimal detection of ALK-rearranged lung adenocarcinomas." J Thoracic Oncol 8: 322-328.
Articles for notation
Cho A et al. "NSCLC subtype prediction using cytologic fluid specimens from needle aspiration biopsies." Am J Clin Pathol 139: 309-316.
Conde E et al. "The ALK translocation in advanced non-small-cell lung carcinomas: preapproval testing experience at a single cancer centre." Histopathology 62, 609-616.
Friboulet L et al. "ERCC1 isoform expression and DNA repair in non-small cell lung cancer." NEJM 368: 1101-1110.
Ishii J et al. "POU domain transcription factor BRN2 is crucial for expression of ASCL1, ND1 and neuroendocrine marker molecules and cell growth in small cell lung cancer." Pathol International 63: 158-168.
Kadota K et al. "Thyroid transcription factor-1 expression is an independent predictor of recurrence and correlates with the IASLC/ATS/ERS histologic classification in patients with stage I lung adenocarcinoma." Cancer 119: 931-938.
Lee AF et al. "IMP3 and GLUT-1 immunohistochemistry for distinguishing benign from malignant mesothelial proliferations." Am J Surg Pathol 37: 421-426.
Liu CY et al. "Prognostic factors in resected pathological N1-stage II nonsmall cell lung cancer." Eur Respir J 41: 649-655.
Ordonez NG. "Mesothelioma with signet-ring cell features: report of 23 cases." Mod Pathol 26: 370-384.
Steinfort DP et al. "Radial probe EBUS versus CT-guided needle biopsy for evaluation of peripheral pulmonary lesions: an economic analysis." Eur Respir J 41: 539-547.
William J et al. "Lymphoproliferative neoplasms of the lung: a review." Arch Pathol Lab Med 137: 382-391.
DeNicola MM et al. "Pathologic findings in lung allografts with anti-HLA antibodies." J of Heart and Lung Transplantation 32:326-332.
Furuya M, Nakatani Y. "Birt-Hogg-Dube syndrome: clinicopathological features of the lung." J Clin Pathol 66: 178-186.
Nakajima N et al. "Pathological study of archival lung tissue from five fatal cases of avian H5N1 influenza in Vietnam." Mod Pathol 26: 357-369.
Ofek E et al. "Restrictive allograft syndrome post lung transplantation is characterized by pleuroparenchymal fibroelastosis." Mod Pathol 26: 350-356.
Yarmus L et al. "Cyroprobe transbronchial lung biopsy in patients after lung transplantation." Chest. 143(3): 621-626.