Welcome to the August edition of Pulmonary Pathology Reviews, a multi-institutional journal club intended to help all of us keep pace with the information overload that has become the bain of medical professionals in every discipline. Good news for those interested in pulmonary pathology is that Cherise Cortese of Mayo Clinic Florida did the work for us this month by browsing all relevant articles published in July journals and reviewing those of greatest interest in our rescheduled teleconference on Monday, September 8th. What follows is her OVERVIEW summarizing what's hot and what's not, and an ARTICLE INDEX with links to PubMed abstracts (and full text of articles if your institutional access allows it). Click here if you want her PDF summary which includes all of the essential facts (usually beats reading the full articles!). And click here if you want to listen to or download (MP3 audiofile) the actual teleconference exactly as it went down at 09:15 on 9/8/2014.
There was an abundance of articles discussing neoplastic lung disease this month. I will highlight a few of them that I think are interesting. Churg et al describes invasive papillary mesothelioma, which can be recurrent and multifocal. Tsuta et al describes morule-like components in lung adenocarcinoma, which we have all seen but probably paid little attention to in the past. These portend an unfavorable prognosis. Raparia et al discusses lung adenocarcinomas that mimic DIP and can be difficult to identify. There is an article by Dembitzer et al looking at lobar vs sublobar resections in lung cancer, a controversial topic. The one article I will discuss on non-neoplastic lung is one with an impressive number of pulmonary cysts that were reviewed in BHDS patients. The results are interesting in that the authors suggest we can tell the difference between them and inflammatory cysts.
In the articles for notation, there are a few that discuss the feasibility of testing on cytology smears. Lee et al looked at mucinous adenocarcinomas and diagnosis by core needle biopsy. Wu et al looked at the cell transfer technique on FNA smears for detecting KRAS and EGFR. One article looks at molecular profiling using pleural effusion.
Fonseca et al had an interesting article showing that there is massive incongruency among clinicians in classifying multiple foci of lung cancers. I thought her study was eye-opening. There was a good article on the differences in arteries and arterioles in COPD and IPD, not only in gene expression but also histologically. One article highlighted use of inflating small lung wedges at frozen section to better identify lesions and looked at the differences in the sizes of the lesions from macroscopic to microscopic to radiologic assessment. They give a nice description of their procedure, which seems to work for them. Ciliated muconodular papillary tumor of the lung is again presented and discussed; we visited this entity back in 2012 – looks a lot like mucinous adenocarcinoma to me. EGFR and KRAS were mentioned several times this month – a hot topic.
Enjoy this month’s articles!
Articles for Discussion
Churg, et al. Well-differentiated Papillary Mesothelioma with Invasive Foci. Am J Surg Path, 2014;39:990-998.
Tsuta, et al. Primary lung adenocarcinoma with morule-like components: A unique histologic hallmark of aggressive behavior and EGFR mutation. Lung Cancer 2014;85:12-18.
Dembitzer, et al. Impact of Histologic Subtyping on Outcome in Lobar vs Sublobar Resections for Lung Cancer: A Pilot Study. Chest 2014;146(1):175-181.
Raparia, et al. Lung Tumors Masquerading as Desquamative Interstitial Pneumonia (DIP): Report of 7 cases and Review of the Literature. Am J Surg Pathol 2014;38:921-924.
Kumasaka, et al. Characterization of pulmonary cysts in Birt-Hogg-Dube syndrome: histopathological and morphometric analysis of 229 pulmonary cysts from 50 unrelated patients. Histopathology 2014;65:100-110.
Articles for Notation - Neoplastic Lung Disease
Canizares et al. Atypical carcinoid tumors of the lung: prognostic factors and patterns of recurrence. Thorax 2014;69:648-653.
Lee, et al. Clinical Outcome According to the Level of Preexisting Epidermal Growth Factor Receptor T790M Mutation in Patients With Lung Cancer Harboring Sensitive Epidermal Growth Factor Receptor Mutations. Cancer 2014; 120:2090-8.
Gomez, et al. Alterations in the Expression of p53, KLF4, and p21 in Neuroendocrine Lung Tumors. Arch Pathol Lab Med 2014;138:936-942.
Isaka, et al. Comparison between CT tumor size and pathological tumors size in frozen section examinations of lung adenocarcinoma. Lung Cancer 2014:85;40-46.
Wu et al. Utilization of cell-transferred cytologic smears in detection of EGFR and KRAS mutation on adenocarcinoma of lung. Modern Path 2014:27;930-935.
Wang, et al. Immunohistochemical screening and fluorescence in situ hybridization confirmation of ALK translocation in lung adenocarcinoma and its clinicopathological significance: a single-center large-scale investigation of Chinese patients. Human Pathology 2014:45;1414-1422.
Lee et al. Reliability of small biopsy or cytology for the diagnosis of pulmonary mucinous adenocarcinoma. J Clin Pathol 2014;67:587-591.
Morton, et al. Identification of mRNAs and lincRNAs associated with lung cancer progression using next-generation RNA sequencing from laser micro-dissected archival FFPE tissue specimens. Lung Cancer 2014;85:31-39.
Akamatsu, et al. Multiplexed Molecular Profiling of Lung Cancer Using Pleural Effusion. J Thorac Oncol 2014;9:1048-1052.
Fonseca, et al. How many names for a rose: Inconsistent classification of multiple foci of lung cancer due to ambiguous rules. Lung Cancer 2014:85;7-11.
Ibrahim, et al. Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition. Human Path 2014:45;1397-1405.
deCastro, et al. Erythrocyte Fatty Acids as Potential Biomarkers in the Diagnosis of Advanced Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, and Small Cell Lung Cancer. Am J Clin Pathol 2014;142:111-120.
Non-Neoplastic Lung Disease
Hoffman et al. Distinct Differences in Gene Expression Patterns in Pulmonary Arteries of Patients with Chronic Obstructive Pulmonary Disease and Idiopathic Pulmonary Fibrosis with Pulmonary Hypertension. Am J Respir Crit Care Med 2014;190:98-111.
Todd et al. Update in Lung Transplantation 2013. Am J Respir Crit Care Med 2014;190:19-24.
McBrien et al. Recurrent pneumothoraces in a 17-year-old-man with mixed connective tissue disease. Thorax 2014;69:685-686.
Chuang et al. Ciliated muconodular papillary tumor of the lung: A newly defined peripheral pulmonary tumor with conspicuous mucin pool mimicking colloid adenocarcinoma: A case report and review of the literature. Path Internatl 2014;64:352-357.
Smith et al. At the intersection of primary pulmonary myxoid sarcoma and pulmonary angiomatoid fibrous histiocytoma: observations from three new cases. Histopathology 2014;65:142-148.
Muramatsu et al. Malignant pleural mesothelioma mimicking the intrapulmonary growth pattern of epithelioid hemangioendothelioma. Path International 2014;64:358-360.