Today brings the latest edition of Pulmonary Pathology Reviews, a blog to share materials generated in support of a monthly, multi-institutional journal club in which like-minded inhabitants of some of North America's shiniest ivory towers interrogate the peer-reviewed literature for knowledge-nuggets worthy of consideration by anyone interested in the world of pulmonary pathology. Today's version comes to you from Tom Colby in sunny Scottsdale, AZ where his Mayo Clinic Arizona colleagues frequently ask of their Minnesota colleagues, "Winter? What winter?" His OVERVIEW follows (with links to PubMed abstracts) and offers a high level overview of what's hot and what's not. Click here if you want to check-out his PDF summary of the 14 articles chosen for discussion or notation, all of which hit the print literature in January 2014. And if you want to hear the teleconference exactly as it went down at 07:15 MST on Monday, February 24th, click here to download an MP3 audiofile (but be patient, may take awhile depending on your bandwidth).
There were not too many articles in January that I flagged for presentation at Journal Club. One of the most interesting is a description of an outbreak of pulmonary disease putatively ascribed to humidifier disinfectant in Korea. Despite what may be some methodology issues in the study, there are interesting findings including pathologic changes that appear relatively new and I will be interested to hear the discussion during Journal Club.
Shames and Wistuba present a nice overview of genomic classification of lung cancer that appears relatively up to date and has some nice figures that could be used for talks. The specifics are beyond my expertise.
Rossi, et al. make the case that virtually all large-cell carcinomas of the lung, at least as defined by WHO criteria, can generally be put into one of the following categories with immunohistochemical and molecular characterization: adeno, squamous, large-cell neuroendocrine. They provide a conceptual algorithm for their approach.
In a large study from Japan, Tsutani argues that for selected ground glass predominant adenocarcinomas that are clinical stage 1A, wedge resection or segmentectomy is an acceptable alternative treatment to traditional lobectomy. This study is again retrospective and the literature is in dire need of a prospective study supporting this approach.
There are a number of interesting papers under “Articles for Notation” including a description of a computerized automated CT scan tool to assess the progression of interstitial lung disease.
There is another paper from the Japanese (Minato, et al.) looking at various markers for distinguishing reactive mesothelial hyperplasia from mesothelioma. There is nothing new here although the markers do seem to be getting more specific but they are not absolutely perfect.
Finally, for those that are in need of educating their colleagues, there is a description of performance validation in anatomic pathology in which a group showed how it could implement the new adenocarcinoma classification (see Murugan, et al.).