Welcome to the latest edition of Pulmonary Pathology Reviews, a multi-institutional journal club focusing on current literature relevant to pulmonary pathology. The October 2014 journal club comes to you courtesy of Joe Maleszewski at the world famous Mayo Clinic in Rochester, MN. He focuses on articles published in September in journals commonly canvassed by our participants. His OVERVIEW follows and provides a summary of what's hot and what's not. An ARTICLE INDEX includes links to PubMed abstracts and full text articles if your institution is appropriately licensed. Click here to download a pdf of his article summaries. Click here if you want to hear the teleconference as it went down at 08:15 CDT on Monday, October 27, 2014.
There were 29 articles relevant to pulmonary pathology during the month of September. As usual, the lion’s share were on various topics of neoplastic disease, while only 2 were related to non-neoplastic topics. Four papers were chosen for more in-depth discussion.
Izar and colleagues present compelling data on relevance for routine KRAS testing in stage I lung adenocarcinoma. Althogh specific therapeutic implications are not necessarily derived from results of such testing, important prognostic information appears to be conveyed through not only the presence of KRAS mutations, but also in the specific type of mutation.
Douillard et al. evaluate the concordance of using circulating free DNA as a surrogate for direct tumor testing of EGFR status. Interestingly, the performance characteristics look promising although the authors concede that the test is not yet able to supplant direct testing.
I chose the article by Mansuet-Lupo and colleagues either out of optimism, naiveté, or some combination thereof. Unfortunately, it really disappointed. The title made me think it was going to be a more critical appraisal of the new classification system with a discussion of some of the issues with reproducibility and the like. It did little to advance the difficult issues with the classification, however.
Lastly, Lewis et al. took a contemporary look at lung cancer trends in the United States. They reviewed demographic and histologic trends and presented a nice picture overall. They touched on obvious issues such as the increased utilization of IHC and its impact on classification and molecular tools as well. Overall, a nice snapshot of the terrain in lung cancer pathology - so update your medical school lecture slides accordingly!
Articles for Discussion
Izar et al. The Prognostic Impact of KRAS, Its Codon and Amino Acid Specific Mutations, on Survival in Resected Stage I Lung Adenocarcinoma. J Thorac Oncol. 2014 Sep;9(9): 1363-9.
Douillard JY et al. Gefitinib treatment in EGFR mutated caucasian NSCLC: circulating-free tumor DNA as a surrogate for determination of EGFR status. J Thorac Oncol. 2014 Sep;9(9):1345-53.
Mansuet-Lupo A et al. The new histologic classification of lung primary adenocarcinoma subtypes is a reliable prognostic marker and identifies tumors with different mutation status: the experience of a French cohort. Chest. 2014 Sep;146(3):633-43.
Lewis DR et al. US lung cancer trends by histologic type. Cancer. 2014 Sep 15;120(18):2883-92.
Articles for Notation
Hutarew G et al. Immunohistochemistry as a screening tool for ALK rearrangement in NSCLC: evaluation of five different ALK antibody clones and ALK FISH. Histopathology. 2014 Sep;65(3):398-407.
Cutz JC et al. Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. J Thorac Oncol. 2014 Sep;9(9):1255-63.
Schmidt LH et al. Prognostic impact of Bcl-2 depends on tumor histology and expression of MALAT-1 lncRNA in non-small-cell lung cancer. J Thorac Oncol. 2014 Sep;9(9):1294-304.
Thomas R et al. Catheter tract metastasis associated with indwelling pleural catheters. Chest. 2014 Sep;146(3):557-62.
Yang YC et al. DNMT3B overexpression by deregulation of FOXO3a-mediated transcription repression and MDM2 overexpression in lung cancer. J Thorac Oncol. 2014 Sep;9(9):1305-15.
Zhang Q et al. EGFR mutations and clinical outcomes of chemotherapy for advanced non-small cell lung cancer: A meta-analysis. Lung Cancer 85(2014): 339-45.
Nakamura R et al. Epidermal growth factor receptor mutations: effect on volume doubling time of non-small-cell lung cancer patients. J Thorac Oncol. 2014 Sep;9(9):1340-4.
Liu J et al. Serum free fatty acid biomarkers of lung cancer. Chest. 2014 Sep;146(3):670-9.
Wu HM et al. Reversed expression of GRIM-1 and GRP78 in human non-small cell lung cancer. Hum Pathol. 2014 Sep;45(9):1936-43.
Yoshizawa A et al. HER2 status in lung adenocarcinoma: a comparison of immunohistochemistry, fluorescence in situ hybridization (FISH), dual-ISH, and gene mutations. Lung Cancer. 2014 Sep;85(3):373-8.
Queisser MA et al. HOIL-1L Functions as the PKCζ Ubiquitin Ligase to Promote Lung Tumor Growth. Am J Respir Crit Care Med. 2014 Sep 15;190(6):688-98.
Zhang C et al. Evaluation of napsin A, TTF-1, p63, p40, and CK5/6 immunohistochemical stains in pulmonary neuroendocrine tumors. Am J Clin Pathol. 2014 Sep;142(3):320-4.
Ichinose J et al. Prognostic impact of the current Japanese nodal classification on outcomes in resected non-small cell lung cancer. Chest. 2014 Sep;146(3):644-9.
Edelman MJ et al. GP88 (progranulin): a novel tissue and circulating biomarker for non-small cell lung carcinoma. Hum Pathol. 2014 Sep;45(9):1893-9.
Thunnissen E et al. Reproducibility of histopathological diagnosis in poorly differentiated NSCLC: an international multiobserver study. J Thorac Oncol. 2014 Sep;9(9):1354-62.
Denholm R et al. Is previous respiratory disease a risk factor for lung cancer? Am J Respir Crit Care Med. 2014 Sep 1;190(5):549-59.
Dabir S et al. RET mutation and expression in small-cell lung cancer. J Thorac Oncol. 2014 Sep;9(9):1316-23.
Rudin CM et al. RET mutations in neuroendocrine tumors: including small-cell lung cancer. J Thorac Oncol. 2014 Sep;9(9):1240-2.
Adam P et al. Thymoma with loss of keratin expression (and giant cells): a potential diagnostic pitfall. Virchows Arch. 2014 Sep;465(3):313-20.
Ishii J et al. Class III/IV POU transcription factors expressed in small cell lung cancer cells are involved in proneural/neuroendocrine differentiation. Pathol Int. 2014 Sep;64(9):415-22.
Seo AN et al. Performance characteristics of nested polymerase chain reaction vs real-time polymerase chain reaction methods for detecting Mycobacterium tuberculosis complex in paraffin-embedded human tissues. Am J Clin Pathol. 2014 Sep;142(3):384-90.
Flaherty KR et al. Smoking-related idiopathic interstitial pneumonia. Eur Respir J. 2014 Sep;44(3):594-602.
Case Reports / Letters to the Editor
Roth A et al. A rare case of an EML4-ALK-rearranged lung adenocarcinoma missed by in situ-hybridization but detected by RT-PCR. J Clin Pathol. 2014 Jul 15. pii: jclinpath-2014-202394.
Durra H et al. Mediastinal adenofibroma: a case report. Histopathology. 2014 Sep;65(3):434-5.