Welcome to the latest Pulmonary Pathology Reviews, a monthly multi-institutional journal club intended to keep ourselves and others in the know when it comes to the latest developments of interest to the pulmonary pathology community. This month's review comes from Joanne Yi at the Mayo Clinic in Rochester, MN. What follows is her OVERVIEW, summarizing the highs and lows in peer reviewed articles in print in March 2016. An ARTICLE INDEX comes after with links to PubMed abstracts for those articles that made the list. Click here for a PDF of Joanne's summary of each article, saving you the time of having to read each in more detail than may be necessary. And click here if you want to here the teleconference as it went down on Monday, April 25th, at 8:15 CDT.
Eighteen original articles were identified from our target journals published in March of 2016; only five were on non-neoplastic diseases and the remaining 13 were on neoplastic diseases. I also included four case reports that seemed to be interesting. Proceedings from the 2015 PPS meeting held in San Francisco were published in Archives of Pathology and Laboratory Medicine, which should be a good reading for assorted timely topics of pulmonary pathology. I chose four articles were for discussion to encompass both neoplastic and non-neoplastic diseases.
Nicholson et al reported the IASLC staging project on small cell lung cancer (SCLC) in the forthcoming 8th edition of the TNM classification for lung cancer. They compared the performance of descriptors in 7th and proposed 8th edition on SCLC and claimed a prognostic value of TNM staging in SCLC patients.
Weichert et al proposed a grading scheme for pulmonary squamous cells carcinoma using a combined score based on tumor budding and tumor nest size. The applicability of this system is yet to be seen by additional studies in the future.
Boon et al did morphometric analysis on the explant lungs from cystic fibrosis patients using ex vivo CT (multidetector CT followed by micro CT and histologic examination). They found a marked reduction in the number and size of terminal bronchioles as well as the abnormalities in the larger airways.
Jackson et al checked the accuracy of diagnostic testing in primary ciliary dyskinesia (PCD) and concluded that combination testing is ideal. Although genuine PCD is rare, there is a fairly large population who might undergo various testing based on somewhat nonspecific symptoms. They investigated the performances of transmission electron microscopy, high-speed video microscopy analysis that is not available in the US yet, and nasal nitric oxide measurement.
Two of our journal club members published very interesting papers in March. Boland et al reported a study on interobserver variability in the diagnosis of AIS, MIA and invasive adenocarcinoma. Butnor et al reported the cases of synchronous lung cancer and diffuse mesothelioma, which is the largest series in the literature to date. There were a few notable papers on small cell lung cancers in addition to the one by Nicholson et al for discussion: SLCL with EGFR mutations and SCLC occurring in never smokers possibly associated with radon given the high residential radon exposure found in these patients from northern Spain. I was kind of disappointed about the paper by Taioli et al on survival after sublobar resection for early-stage lung cancer because they concluded that the comparing with its efficacy to that of lobectomy was not possible due to methodological obstacles.
Among the few papers on non-neoplastic diseases, I found two papers were very interesting. The study by Cohen et al, in which three notable pathologists in the field (including Andy Churg, Jerry Abraham and Francis Green) participated for histopathologic analysis, demonstrated that rapidly progressive pneumoconiosis in US coal workers was associated with exposure to coal mine dust containing high concentrations of respirable silica and silicates. Galambos et al brought up provocative new thoughts about the origin of plexiform lesion as a letter to the editor published in the blue journal. They claimed that there is histologic evidence supporting a potential role of the bronchial circulation and intrapulmonary bronchopulmonary anastomotic pathways in the pathobiology of idiopathic pulmonary arterial hypertension (IPAH). They proposed that the bronchial circulation may further contribute to the development of plexiform and dilatation lesion in severe IPAH. Obviously, more study would be needed to prove or refute this theory.
Articles for discussion
Nicholson AG et al. The IASLC Staging Project: Proposals for the revision of the clinical and pathologic staging of small cell lung cancer in the forthcoming eighth edition of the TNM classification for lung cancer. J Thorac Oncol 2016;3:300-11
Weichert W et al. Proposal of a prognostically relevant grading scheme for pulmonary squamous cell carcinoma. Eur Respir J 2016;47:938-46
Boon M et al. Morphometric analysis of explant lungs in cystic fibrosis. Am J Respir Crit Care Med 2016;193:516-26
Jackson CL et al. Accuracy of diagnostic testing in primary ciliary dyskinesia. Eur Respir J 2016;47:837-48
Article for notation
Boland JM et al. AIS, MIA, and invasive pulmonary adenocarcinoma-analysis of interobserver agreement, survival, radiographic characteristics and gross pathology in 296 nodules. Hum Pathol 2016;51:41-50
Butnor KJ et al. Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases. Lung Cancer 2016;95:1-7
Wang Q et al. Antibody 1A4 with routine immunohistochemistry demonstrates high sensitivity for ALK rearrangement screening of Chinese lung adenocarcinoma patients: A single-center large-scale study. Lung Cancer 2016;95:39-43
Karasaki T et al. Identification of individual cancer-specific somatic mutations for neoantigen-based immunotherapy of lung cancer. J Thorac Oncol 2016;11:324-33
Siegele BJ et al. Epidermal growth factor receptor mutations in small cell lung cancers: Two cases and a review of the literature. Lung Cancer 2016;95:65-72
Li BT et al. HER2 amplification and HER2 mutation are distinct molecular targets in lung cancers. J Thorac Oncol 2016;11:414-9
Sakakura N et al. Estimation of the pathological invasive size of pulmonary adenocarcinoma using high-resolution computed tomography of the chest: A consideration based on lung and mediastinal window settings. Lung Cancer 2016;95:51-6
Steuer CE et al. Role of race in oncogenic driver prevalence and outcomes in lung adenocarcinoma: Results from the lung cancer mutation consortium. Cancer 2016;122:766-72
Torres-Duran M et al. Small cell lung cancer in never-smokers. Eur Respir J 2016;47:947-53
Rivoisy C et al. Thymic epithelial tumor-associated cytopenia: A 10-year observational study in France. J Thorac Oncol 2016;11:391-99
Taioli E et al. Survival after sublobar resection for early-stage lung cancer: Methodological obstacles in comparing the efficacy to lobectomy. J Thorac Oncol 2016;11:400-6
Cohen RA et al. Lung pathology in US coal workers with rapidly progressive pneumoconiosis implicates silica and silicates. Am J Respir Crit Care Med 2016;193:673-80
Grunewals J et al. T-cell receptor-HLA-DRB1 associations suggest specific antigens in pulmonary sarcoidosis. Eur Repir J 2016;47:898-909
Galambos C et al. Intrapulmonary bronchopulmonary anastomoses and plexiform lesions in idiopathic pulmonary arterial hypertension. Am J Respir Crit Care Med 2016;193: 574-6
de Kock L et al. Germline and somatic DICER1 mutations in a well-differentiated fetal adenocarcinoma of the lung. J Thorac Oncol 2016;11:e31-3
Nakashima K et al. Organizing pneumonia induced by nivolumab in a patient with metastatic melanoma. J Thorac Oncol 2016;11:432-3
Page Derks JL et al. Neuroendocrine cancer of the lung: A diagnostic puzzle. J Thorac Oncol 2016;11:e35-8
Kokho N et al. Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review. Hum Pathol 2016;51:57-63
PPS 2015 Proceedings/Reviews, Abstracts
Smith ML. Update on pulmonary fibrosis. Not all fibrosis is created equally. Arch Pathol Lab Med 2016;140:221-9
Roden AC and Yi ES. Pulmonary Langerhans cell histiocytosis. An update from the pathologists’ point of view. Arch Pathol Lab Med 2016;140:230-40
Thunnissen E et al. Ex vivo artifacts and histopathologic pitfalls in the lung. Arch Pathol Lab Med 2016;140:212-20
Bernicker E. Next-generation sequencing and immunotherapy biomarkers. A medical oncology perspective. Arch Pathol Lab Med 2016;140:245-8
Husain AN and Garrity ER. Lung transplantation. The state of the airways. Arch Pathol Lab Med 2016;140:241-4
Abstracts from the PPS 2015 biennial meeting. Arch Pathol Lab Med 2016;140:255-66