Welcome to the latest edition of Pulmonary Pathology Reviews, coming to us courtesy of Andras Khoor, Chair of Laboratory Medicine and Pathology at Mayo Clinic Florida in sunny Jacksonville! What follows is his OVERVIEW highlighting those articles chosen for discussion. Scroll a little further and you'll get to the ARTICLE INDEX, listing all articles worthy of consideration from the December 2014 print literature including links to PubMed abstracts. Click here for a PDF version of his summary of not only discussion articles but also those included for notation. If you want to hear the teleconference, complete with irritating buzzing just as we too experienced it, click here to download MP3 audiofile (may take awhile to download depending on bandwidth of your connection).
Welcome to the first Pulmonary Pathology Journal Club of the year! I have found 32 relevant articles in our regularly reviewed 22 journals and have selected 7 for discussion. Five of these are original articles 2 are editorial commentaries.
Meyer et al. have published new ISHLT/ATS/ERS clinical practice guidelines for the diagnosis and management of bronchiolitis obliterans syndrome (BOS). The article also clarifies the differences among chronic lung allograft dysfunction (CALD), BOS, and obliterative bronchiolitis (OB).
The paper by Yang et al. and the corresponding editorial by Selman and Pardo reveal the role of DNA methylation in the development of idiopathic pulmonary fibrosis.
Takei et al. call attention to Epstein-Barr virus-positive pleural effusion and describe its cytomorphologic characteristics.
Kameyama et al. in their original article and Gonzales-Rivas and Rami-Porta in their editorial argue that intraoperative pleural lavage cytology has a significant role in lung cancer staging.
Last but not least, our own Jennifer Boland and Joanne Yi have published an interesting article with their collaborators on pulmonary adenocarcinoma with signet ring cell features.
Enjoy the reviews and summaries and have a happy New Year!
Articles for Discussion
Meyer et al. An international ISHLT/ATS/ERS clinical practice guideline: diagnosis and management of bronchiolitis obliterans syndrome. Eur Respir J 2014;44:1479–1503.
Yang et al. Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 2014; 190: 1263–1272.
Selman and Pardo. Stochastic Age-related Epigenetic Drift in the Pathogenesis of Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med 2014; 190: 1328-1330.
Takei and Mody. Epstein-Barr Virus–Positive Pleural Effusion Clinical Features, Cytomorphologic Characteristics, and Flow Cytometric Immunophenotyping. Am J Clin Pathol 2014; 142: 788-794.
Kameyama et al. Prognostic value of intraoperative pleural lavage cytology for non–small cell lung cancer: The influence of positive pleural lavage cytology results on T classification. J Thorac Cardiovasc Surg 2014; 148: 2659-64.
Gonzalez-Rivas and Rami-Porta. Intraoperative pleural lavage cytology: More evidence on its prognostic and staging values. J Thorac Cardiovasc Surg 2014; 148: 2665-6.
Boland et al. Pulmonary Adenocarcinoma With Signet Ring Cell Features: A Comprehensive Study From 3 Distinct Patient Cohorts. Am J Surg Pathol 2014; 38: 1681-1688.
Articles for Notation
Schiavon et al. COPD-related adenocarcinoma presents low aggressiveness morphological and molecular features compared to smoker tumours. Lung Cancer 2014; 86: 311-317.
Russell et al. Prevalence, morphology, and natural history of FGFR-amplified lung cancer, including squamous cell carcinoma, detected by FISH and SISH. Mod Pathol 2014; 27; 1621–1631.
Vidal et al. Assessment of ALK Status by FISH on 1000 Spanish Non-Small Cell Lung Cancer Patients. J Thorac Oncol. 2014; 9: 1816–1820.
Bordi et al. Gene mutations in small-cell lung cancer (SCLC): Results of a panel of 6 genes in a cohort of Italian patients. Lung Cancer 2014; 86: 324-328.
Asiedu et al (Marie-Christine Aubry is a co-author). Generation and Sequencing of Pulmonary Carcinoid Tumor Cell Lines. J Thorac Oncol 2014; 9: 1763–1771.
Masai et al. Cytokeratin 19 expression in primary thoracic tumors and lymphnode metastases. Lung Cancer 2014; 86: 318-323.
Takeda et al. Comparison of genomic abnormality in malignant mesothelioma by the site of origin. J Clin Pathol 2014; 67: 1038–1043.
Koh et al. A comprehensive immunohistochemistry algorithm for the histological subtyping of small biopsies obtained from non-small cell lung cancers. Histopathology 2014, 65, 868–878.
Lonardo et al. Maspin expression patterns differ in the invasive versus lepidic growth pattern of pulmonary adenocarcinoma. Histopathology 2014; 65: 757– 763.
Zhang et al A Comprehensive Investigation of Molecular Features and Prognosis of Lung Adenocarcinoma with Micropapillary Component. J Thorac Oncol. 2014; 9: 1772–1778.
Mairinger et al. Different micro-RNA expression profiles distinguish subtypes of neuroendocrine tumors of the lung: results of a profiling study. Mod Pathol 2014; 27, 1632–1640.
VandenBussche et al. Molecular alterations in non–small cell lung carcinomas of the young. Hum Pathol 2014; 45: 2379–2387.
Bondgaard et al. High specificity but low sensitivity of mutation-specific antibodies against EGFR mutations in non-small-cell lung cancer. Mod Pathol 2014; 27: 1590–1598.
Kinoshita et al. Prognostic Factors Based on Clinicopathological Data Among the Patients with Resected Peripheral Squamous Cell Carcinomas of the Lung. J Thorac Oncol. 2014; 9: 1779–1787.
Yamada et al. Tumor-size-based morphological features of metastatic lymph node tumors from primary lung adenocarcinoma. Pathology International 2014; 64: 591–600.
Crystal. Airway Basal Cells: The “Smoking Gun” of Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med 2014; 190: 1355–1362.
Lucas and Leigh. Diagnosis of primary ciliary dyskinesia: Searching for a gold standard. Eur Respir J 2014; 44: 1418–1422.
Zhang, Deng, and Cagle. Utility of Immunohistochemistry in the Diagnosis of Pleuropulmonary and Mediastinal Cancers: A Review and Update. Arch Pathol Lab Med 2014; 138: 1611–1628.
Ricciardi et al. NSCLC and HER2: Between Lights and Shadows. J Thorac Oncol. 2014; 9: 1750–1762.
Moreira and Eng. Personalized Therapy for Lung Cancer. Chest 2014; 146: 1649-1657.
Grosu et al. Critical Airway Obstruction due to Pseudomembranous Aspergillus tracheitis. Am J Respir Crit Care Med 2014; 190: e65–e66.
Kim et al. Multifocal synchronous mucinous adenocarcinomas arising in congenital pulmonary airway malformation: a case report with molecular study. Histopathology 2014; 65: 926–932.
Umezawa et al. Pulmonary Artery Intimal Sarcoma. Am J Respir Crit Care Med 2014; 190: e67–e68.
Okudela et al. A case of pulmonary hamartoma with distinctive histopathological features: A discussion of its differential diagnosis and histogenesis. Pathology International 2014; 64: 618–623.
Kulkarni and Rosenbluth. Cavitary Lung Nodules in a Patient with Prior Squamous Cell Carcinoma of the Submandibular Gland. Am J Respir Crit Care Med 2014; 190: 1447–1448.