Our first edition of Pulmonary Pathology Reviews came to us courtesy of Andras Khoor, Chair of Laboratory Medicine and Pathology at Mayo Clinic Florida, on Monday, January 25th. What follows is his OVERVIEW, summarizing what's hot and what's not in articles published in the peer reviewed literature in December 2015. Click here if you want his PDF article summaries - a CliffNotes version of sorts to help you get to the meat of the thing without having to actually read all of the articles! Andras' OVERVIEW is followed by an ARTICLE INDEX with links to the PubMed abstracts for the articles included in his summary. And if you want to hear the teleconference as it went down at 09:15 EST on that fateful day, click here to download an MP3 audiofile (patience . . . depending on your internet connection this step may take a few minutes).
Happy New Year and thank you for your interest in our Pulmonary Pathology Journal Club! The first Journal Club of 2016 focuses on the last articles of 2015. Interestingly, in last December, the majority of pulmonary pathology related articles were reviews and case reports. These are also worth reading, but the papers we discuss are original articles.
The aim of the article by Omote et al. is to elucidate the clinical, radiologic, and histologic features of lung-dominant connective tissue diseases. Interestingly, the most common histologic pattern was usual interstitial pneumonia (UIP) followed by nonspecific interstitial pneumonia, which is in contrast with our previous understanding of interstitial pneumonias in patients with connective tissue diseases. Another interesting point is that, based on the multidisciplinary discussion, 18 of the 25 patients with histologic UIP were considered to have unclassifiable idiopathic interstitial pneumonia, whereas 7 patients were considered to have idiopathic pulmonary fibrosis. The usage of terms might be an interesting topic for discussion.
Ikeda et al investigated copy number alterations in the programmed death ligand 1 (PD-L1) and Janus kinase 2 (JAK2) genes. Correlation between PD-L1 amplification and prognosis and PD-L1 amplification and JAK2 amplification was also investigated.
Lim et al examined the effect of research biopsy requirements on the enrollment of patients with advanced NSCLC in clinical trials in Toronto, Canada. It will be interesting to hear if our colleagues have had similar experience in the United Stated.
Finally, Michels et al have analyzed clinicopathological characteristics of RET rearranged lung adenocarcinomas in European patients. Enjoy the reviews and discussions!
Articles for Discussion
Omote et al. Lung-Dominant Connective Tissue Disease: Clinical, Radiologic, and Histologic Features. Chest. 2015;148:1438-46.
Ikeda et al. PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer. J Thorac Oncol. 2016:11:62-71.
Lim et al. Patients with Advanced Non-Small Cell Lung Cancer: Are Research Biopsies a Barrier to Participation in Clinical Trials? J Thorac Oncol. 2016;11:79-84.
Michels. Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients. J Thorac Oncol. 2016;11:122-7.
Articles for Notation
Li et al. Clinicopathological significance of fibroblast growth factor 1 in non-small cell lung cancer. Hum Pathol. 2015;46:1821-8.
Schwarz. Autoimmunity: A Pathway to Usual Interstitial Pneumonia? Chest. 2015;148:1367-9.
Cagle and Bernicker. Challenges to Biomarker Testing for PD-1/PD-L1 Checkpoint Inhibitors for Lung Cancer. Arch Pathol Lab Med. 2015;139:1477-8.
Lam and Szabo. Preinvasive Endobronchial Lesions: Lung Cancer Precursors and Risk Markers? Am J Respir Crit Care Med. 2015;192:1411-3.
Lama. Peering into a Rejecting Lung: Can Bronchoalveolar Lavage Exosomes Provide Novel Insights? Am J Respir Crit Care Med. 2015;192:1413-4.
Kropski et al. Personalizing Therapy in Idiopathic Pulmonary Fibrosis: A Glimpse of the Future? Am J Respir Crit Care Med. 2015;192:1409-11.
Minerowicz et al. Calcifying Fibrous Pseudotumor of the Pleura. Am J Respir Crit Care Med. 2015;192:57-8.
Rapicetta et al. A 79-Year-Old Man With Interstitial Lung Disease and Cryptic Area of High 18Fluorodeoxyglucose Uptake in Left Upper Lobe. Chest. 2015;148:e175-80.
Ham et al. Two Cases of Small Cell Lung Cancer Transformation from EGFR Mutant Adenocarcinoma During AZD9291 Treatment. J Thorac Oncol. 2016;11:e1-4.