This month's journal club comes close on the heels of our rescheduled May journal club courtesy of our graduating pulmonary pathology fellow, the ever awesome Martin Ishikawa (surfer boy for short) and yours truly at the University of Michigan Health System (UMHS) in Ann Arbor, MI. We identified 15 articles in our review of the usual list of journals, focusing only on those likely to be of interest in those engaged in the fast paced world of diagnostic surgical pathology of thoracic diseases. A high level OVERVIEW follows after which you will find an ARTICLE INDEX with links to PubMed abstracts and full text versions if your institution allows it. Click here for a PDF summary of individual articles intended to save you some time if you don't want to read the full articles. And if you want to hear the journal club as it went down at 09:15 EDT on Monday, June 27, 2016, click here to download an MP3 audiofile of our 45 minute teleconference. Aloha and mahalo.
Between us Martin and I reviewed what turned out to be a grand total of 15 articles, 4 for discussion and another 11 for your notation including nearly a half dozen case reports.
For discussion we focused on articles with original data including one by Hwang et al. (senior author Andy Churg) in which the authors demonstrate the potential value of p16 FISH and BAP1 IHC in diagnosis of sarcomatoid mesotheliomas. It won’t solve all of your problems but it may solve some of them!
Martin follows up with a paper by our own PulmPathRev member, Jenn Boland, who together with Mayo colleagues showed that if you train and work together you get pretty good at agreeing on the classification of adenocarcinomas. And most importantly, perhaps, classification has value in predicting overall survival in a cohort heavily weighted toward early stage disease.
We take a brief detour into non-neoplastic lung disease to understand a paper by Chiba et al. reviewing the significance of “UIP-like” histology in patients with bird-associated hypersensitivity pneumonia. Spoiler alert . . . they don’t do well.
Our last paper for discussion comes from another PulmPathRev regular, Kelly Butnor, who together with her mentor Vic Roggli looks at a rare subset of mesothelioma patients who have synchronously diagnosed lung cancer. It may not be common but if you don’t know about it you just may miss it altogether when it does!
That’s most of what’s worth knowing. Just when you thought there couldn’t be any more papers about EGFR and ALK testing there are a number of them with a review of PD-L1 thrown in purely for irritation. Not much else new in what are mostly case reports.
Enjoy the articles, and don’t blame us if you don’t like what you read!
Hwang et al. BAP1 Immunohistochemistry and p16 FISH in the Diagnosis of Sarcomatous and Desmoplastic Mesotheliomas. Am J Surg Pathol 2016 May;40(5):714-8.
Boland et al. Adenocarcinoma in situ, minimally invasive adenocarcinoma, and invasive pulmonary adenocarcinoma-analysis of interobserver agreement, survival, radiographic characteristics, and gross pathology in 296 nodules. Hum Pathol 2016 May;51:41-50.
Chiba et al. Chronic Hypersensitivity Pneumonitis with a Usual Interstitial Pneumonia-Like Pattern: Correlation Between Histopathologic and Clinical Findings. Chest 2016 Jun;149(6):1473-81.
Butnor et al. Diffuse malignant mesothelioma and synchronous lung cancer: A clinicopathological study of 18 cases. Lung Cancer 2016 May;95:1-7.
Articles for notation
Wang et al. Antibody 1A4 with routine immunohistochemistry demonstrates high sensitivity for ALK rearrangement screening of Chinese lung adenocarcinoma patients: A single-center large-scale study. Lung Cancer 2016 May;95:39-43.
Sheffield et al. Immunohistochemistry for NF2, LATS1/2, and YAP/TAZ Fails to Separate Benign From Malignant Mesothelial Proliferations. Arch Pathol Lab Med 2016 May;140(5):391.
Kokuho et al. Pulmonary mucosa-associated lymphoid tissue lymphoma associated with pulmonary sarcoidosis: a case report and literature review. Hum Pathol 2016 May;51:57-63.
Ilie et al. Assessment of the PD-L1 status by immunohistochemistry: challenges and perspectives for therapeutic strategies in lung cancer patients. Virchows Arch 2016 May;468(5):511-25.
Jiang et al. Improving Selection Criteria for ALK Inhibitor Therapy in Non-Small Cell Lung Cancer: A Pooled-Data Analysis on Diagnostic Operating Characteristics of Immunohistochemistry. Am J Surg Pathol 2016 May;40(5):697-703.
Ragazzi et al. Diamond: immunohistochemistry versus sequencing in EGFR analysis of lung adenocarcinomas. J Clin Pathol 2016 May;69(5):440-7.
Siegele et al. Epidermal growth factor receptor (EGFR) mutations in small cell lung cancers: Two cases and a review of the literature. Lung Cancer 2016 May;95:65-72.
Dias et al. Association of Pulmonary Cysts and Nodules in a Young Female Patient. Chest 2016 Jun;149(6):e183-90.
Hashmi et al. A Woman in Her 30s With a Past History of HIV Disease Presented With Recurrent Fever, Night Sweats, and Small Bilateral Pulmonary Nodules. Chest Jun;149(6):e177-82.
Ju et al. EGFR, KRAS and ROS1 variants coexist in a lung adenocarcinoma patient. Lung Cancer 2016 May;95:94-7.
Dias et al. Acute Respiratory Distress Syndrome in Lung Paracoccidioidomycosis. Am J Respir Crit Care Med 2016 May 1;193(9):e55-6.