Welcome to the latest edition of Pulmonary Pathology Reviews, coming to us today courtesy of Henry Tazelaar, Chair of the Department of Laboratory Medicine and Pathology at Mayo Clinic Arizona. He canvassed the print literature to identify articles in October 2014 journals worthy of your consideration. In his OVERVIEW below he highlights winners and losers to keep all of us up-to-date when it comes to the fast paced world of pulmonary pathology. His OVERVIEW is followed by an ARTICLE INDEX with links to PubMed abstracts (and full text versions if your institution allows it). Click here for his Table of Contents; click here for his PDF summary, sure to save you some time when compared to reading the articles themselves! And click here if you want to download an audio (MP3) file to hear the teleconference exactly as it went down at 07:15 MST.
Since Thanksgiving is around the corner, it’s a good time to remember to thank fellow journal club members for continuing to work hard through the course of the year to keep us all up-to-date on what’s happening in the pulmonary pathology literature from around the globe. Thanks everyone. I recently looked back at when we started and it’s been 14 years. That’s quite remarkable; thanks to all.
The discussion articles included both papers highlighting non-neoplastic and neoplastic lung disease. While variations in the histologic appearance of nonspecific interstitial pneumonia (NSIP) has been noted since Dr. Katzenstein’s initial descriptions, Kambouchner et al tried to determine the prognostic relevance of histologic variants. The most clinically significant, according to the authors, are those that have a prominent component of organizing pneumonia and those which somewhat resemble diffuse alveolar damage. Righi et al examine the impact of diagnosing non-small-cell lung cancers with the use of immunohistochemistry. In short, tumors with an adenocarcinoma-like IHC profile had survival comparable to that of morphologically defined adenocarcinomas, supporting the use of IHC to optimize lung cancer typing and therapy. Classification of carcinoid tumors appears fairly straight forward according to the WHO, but Swarts et al highlighted the fact that the current classification criteria may need refining. While PAX8 is increasingly being utilized to diagnose thyroid, kidney and Müllerian tumors it has also been recorded in thymic neuroendocrine carcinomas. Toriyama et al compare monoclonal to polyclonal antibodies and conclude that a monoclonal PAX8 is superior to the polyclonal antibody.
There were two large summaries worth tucking away for future reference. Yusen et al report on the 31st adult lung and heart-lung transplant report from the ISHLT while Houston et al report on lung cancer incidence rates and trends by histologic type from 2004-2009.
Kuo et al studied the significance of histologic differentiation, serum CEA and the presence of lymphvascular invasion in stage I lung cancers.
There was no shortage of molecular pathology related articles in keeping with current trends. Kim et al review what type of tissue sampling is required for molecular testing while Marchetti and von Laffert look at multi-institutional and international quality in ALK testing. Villa et al correlate EGFR mutation status with predominant histologic type of adenocarcinoma (the results are similar to those reported by other groups); while Zwaenepoel et al compare multiple immunohistochemical methods of detecting ALK gene rearrangements. There is a nice small series of patients with primary pulmonary myxoid sarcoma (Jeon et al) all of whom had EWSR1-CREB1 translocations.
Wang et al reported on nocardiosis in a large group of patients with lung cancer. Although other sites can of course be infection, the lung is a common location. For those interested in the hazards of water-pipe smoking you may want to check out the article (She et al) and accompanying editorial (Leung et al) in the October issue of Chest. For those interested in thymic pathology in addition to a case report (see below) Huang outlined how the International Thymic Malignancy Interest Group (ITMIG) developed their large centralized database.
To round out this summary, Several case reports this month highlight epithelioid hemangioendothelioma (Albores et al), pulmonary chondroma in Carney’s triad (Mydin et al), combined thymoma and thymic seminoma (Weissferdt et al), AFOP associated with anti-synthetases syndrome (Sauter and our own Kelly Butnor), and nodular lymphoid hyperplasia in a woman with a ruptured silicone breast implant (Karnatovskaia and our own Andras Khoor).
Have a great holiday everyone. Gobble, gobble….
Articles for Discussion
Impact of non-small-cell lung cancer-not otherwise specified immunophenotyping on treatment outcome. Righi et al. J Thorac Oncol. 2014;9:1540-6.
Interobserver variability for the WHO classification of pulmonary carcinoids. Swarts et al. Am J Surg Pathol. 2014;38:1429-36.
Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural and lung tumours: a comparison with polyclonal PAX8 antibody. Toriyama et al. Histopathology. 2014;65:465-72.
Prognostic relevance of histological variants in nonspecific interstitial pneumonia. Kambouchner et al. Histopathology. 2014;65:549-60.
A 40-year-old woman with multilobar nodular densities and massive hemoptysis. Albores et al. Chest. 2014;146(4):e134-e137.
Patterns in lung cancer incidence rates and trends by histologic type in the United States, 2004-2009. Houston et al. Lung Cancer. 2014;86:22-8.
Development of the International Thymic Malignancy Interest Group International Database: An unprecedented resource for the study of a rare group of tumors. Huang et al. J Thorac Oncol. 2014;9:1573-8.
Primary pulmonary myxoid sarcomas with EWSR1-CREB1 translocation might originate from primitive peribronchial mesenchymal cells undergoing (myo)fibroblastic differentiation. Jeon et al. Virchows Arch. 2014;465:453-61.
Tumour tissue sampling for lung cancer management in the era of personalised therapy: what is good enough for molecular testing? Kim et al. Eur Respir J. 2014;44:1011-22.
Prognostic significance of histologic differentiation, carcinoembryonic antigen value, and lymphovascular invasion in stage I non-small cell lung cancer. Kuo et al. J Thorac Cardiovasc Surg. 2014;148:1200-7.
ALK rearrangement testing by FISH analysis in non-small-cell lung cancer patients: results of the first Italian external quality assurance scheme. Marchetti et al. J Thorac Oncol. 2014;9:1470-6.
Calcified pulmonary chondromas in Carney’s triad. Mydin et al. Thorax. 2014;69:969-70.
An immunohistochemical analysis of a newly developed, mouse monoclonal p40 (BC28) antibody in lung, bladder, skin, breast, prostate, and head and neck cancers. Tacha et al. Arch Pathol Lab Med. 2014;138:1358-64.
Correlation of EGFR mutation status with predominant histologic subtype of adenocarcinoma according to the new lung adenocarcinoma classification of the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society. Villa et al. Arch Pathol Lab Med. 2014;138:1353-7.
Multicenter ALK testing in non-small-cell lung cancer: results of a round robin test. von Laffert et al. J Thorac Oncol. 2014;9:1464-9.
Combined thymoma-thymic seminoma. Report of 2 cases of a heretofore unreported association. Weissferdt et al. Human Pathology. 2014;45:2168-72.
Detection of ALK expression in non-small-cell lung cancer with ALK gene rearrangements – comparison of multiple immunohistochemical methods. Zwaenepoel et al. Histopathology. 2014;65:539-48.
Nocardiosis in 132 patients with cancer: microbiological and clinical analyses. Wang et al. Am J Clin Pathol. 2014;142:513-23.
Expanding the spectrum of pulmonary histopathological manifestations of anti-synthetase syndrome: anti-EJ-associated acute fibrinous and organizing pneumonia. Sauter et al. Histopathology. 2014;65:581-5.
Chinese water-pipe smoking and the risk of COPD. She et al. Chest. 2014;146(4):924-31.
Smoke and mirrors: the perils of water-pipe smoking and implications for Western countries. Leung et al. Chest. 2014;146(4):875-6.
The Registry of the International Society for Heart and Lung Transplantation: thirty-first adult lung and heart-lung transplant report – 2014; focus theme: retransplantation. Yusen et al. J Heart Lung Transplant. 2014;33(10):1009-24.
A 60-year-old woman with PET scan-avid lung nodules and a history of a ruptured silicone breast implant. Karnatovskaia et al. Chest. 2014;146(4):e138-e142.