Today brings yet another edition of Pulmonary Pathology Reviews, a multi-institutional journal club intended to help you keep pace with the fast-paced world of pulmonary pathology! Today's journal club comes to us courtesy of Cherise Cortese at Mayo Clinic Florida. What follows is her OVERVIEW summarizing those things worth knowing about in peer reviewed publications that appeared in print journals in August 2016. Her OVERVIEW is followed by an ARTICLE INDEX with links to PubMed abstracts for the articles that she included. Click here for article summaries that Cherise prepared to save you the trouble of having to read them for yourselves. And if you want to hear the teleconference as it went down at 09:15 EDT on Monday, October 3rd, click here to download or stream an MP3 audiofile.
A recurrent them this month is PD-L1. I am reviewing one article that examines the relationship between PD-L1 expression and pathologic features, as well as a few other markers that the authors looked at in their previous papers. Another article that I am reviewing looks at PD-L1 in sarcomatoid lung cancers. I have given you all a copy of the workings of PD-L1 in case you were interested which I found in one of the papers. The UK had a paper discussing their thoughts on PD-L1 as well.
Sarcomatoid carcinomas of the lung are also a recurrent theme. Not only was PD-lL1 expression elucidated, molecular features of some of these cancers was examined. The hope is that we can find a targeted therapy for some of these cancers with a bad prognosis.
Cryobiopsies are discussed in one article. There is a new sheath that can be added onto the cryobiopsy apparatus that allows easier removal of the tissue in the procedure. This method affords larger pieces of tissue, but there was no diagnosis rendered in these biopsies so more work needs to be done, and on humans instead of healthy pigs.
Liquid biopsy is also discussed, although not fully supported by the authors at this time. There needs to be more standardization and a lot more work on liquid biopsy, which we will see more articles about in the future.
There were a few consensus articles that were interesting. Travis et al has a lengthy paper explaining their suggestions for changes in the IASLC Lung Cancer Staging project. This article was geared to not only pathologist, but radiologist too. A consensus reports on mesothelioma was also found this month, with interesting tidbits on potential new causes for mesothelioma and some new treatment regimens.
Hope you enjoy the articles. Talk to you all on Monday morning!
Articles for discussion
Sharma et al. Utility of a novel triple marker (combination of thyroid transcription factor 1, Napsin A, and P40) in the subclassification of non-small cell lung carcinomas using fine-need aspiration cases. Human Pathology 2016:54;8-16.
Yarmus et al. A Randomized Control Trial of a Novel Sheath Cryoprobe for Bronchoscopic Lung Biopsy in a Porcine Model. Chest 2016:150;329-336.
Shimoji et al. Clinical and pathologic features of lung cancer expressing programmed cell death ligand (PD-L1). Lung Cancer 2016:98;69-75.
Vieira et al. Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1) and strong immune-cell infiltration by TCD3 cells and macrophages. Lung Cancer 2016;98:51-58.
Articles for notation
Sousa et al. Amplification of FGFR1 gene and expression of FGFR1 protein is found in different histological types of lung carcinoma. Virchows Archive 2016;469:173-182.
Alberobello et al. P13K as a Potential Therapeutic Target in Thymic Epithelial Tumors. Journal of Thoracic Onc 2016;11:1345-1356
Stewart et al. Elevated integrin a6B4 expression is associated with venous invasion and decreased overall survival in non-small cell lung cancer. Human Path 2016;54:174-183.
Sholl et al. Liquid Biopsy in Lung Cancer: A Perspective From Members of the Pulmonary Pathology Society. Arch Pathol Lab Med 2016:140;825-829.
Terra et al. Molecular characterization of pulmonary sarcomatoid carcinoma: analysis of 33 cases. Modern Pathology 2016;29:824-831.
Desoubeaux et al. Pulmonary toxoplasmosis in immunocompromised patients with interstitial pneumonia: a single-center prospective study assessing PCR-based diagnosis. J Clin Pathol 2016:69;726-730.
Review Articles/Consensus Articles
Cree et al. PD-L1 testing for lung cancer in the UK: recognizing the challenges for implementation. Histopathology 2016:69;177-186.
Travis et al. The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer. J of Thoracic Oncol 2016:11;1204-1223.
Carbone et al. Consensus Report of the 2015 Weinman International Conference on Mesothelioma. Journal of Thoracic Oncol 2016:11;1246-1262.
Cheng et al. Pleuroparenchymal Fibroelastosis of the Lung: A Review. Archives Pathol Lab Med 2016;140:849-853.
Cha et al. Pulmonary Intravascular Lymphomatosis: Clinical, CT, and PET Findings, Correlation of CT and Pathologic Results, and Survival Outcome. Radiology 2016:280;602-610.