Welcome to the last 2016 summer edition of Pulmonary Pathology Reviews, a multi-institutional journal club intended to keep those interested in diagnostic pulmonary pathology in the loop when it comes to the latest information available in peer-reviewed print media. This month's journal club comes to us courtesy of Marie-Christine Aubry and thoracic pathology fellow Roger Hsu at the Mayo Clinic Minnesota, where the women are strong, the men are good looking, and their trainees above average. What follows is her OVERVIEW highlighting what's hot and what's not, and an ARTICLE INDEX with links to PubMed abstracts. Click here to download a PDF of her article summary, the Cliff Notes version of those article worthy of discussion or notation. And if you want to listen in on the teleconference as it went down at 08:15 CDT on Monday, August 29th, click here to download an MP3 audiofile (and be patient - can take awhile depending on your bandwidth).
Only a few, 25, articles were identified in July’s review of journals, with a preponderance (16) covering lung cancer. However, there was no recurrent theme with quite a variety of topics covered. Although there were the usual ALK and PD-L1 papers, this month one could read on PIK3CA, SMAD3, Folate receptors in lung cancers, a few methodology studies looking at tissue yield for EGFR molecular testing from various small biopsies or yield of positive cancer diagnosis in TBNA versus TBBx, two studies on the epidemiology of IPF in Canada and USA, the use of Galectin3 as a predictive serologic marker in ILD.
Choosing the 4 articles for discussion was a difficult decision and I simply used my biased personal interest. Roger, our current pulmonary pathology fellow, assisted with the review and summary.
The first article up for discussion is by Bois et al. entitled “ Could prominent airway-centered fibroblast foci in lung biopsies predict underlying chronic microaspiration in idiopathic pulmonary fibrosis patients?”. I was not influenced in my choice as much by the fact that it was a well done study from our own Joanne Yi, but by the fact that Joanne and I have had a few lively discussions on this topic over the years. So I look forward to my other colleagues’ opinion on the subject.
The second article is from Sanja Dacic out of Pittsburg (“Morphological and molecular approach to synchronous non-small cell lung carcinomas: impact on staging”). The authors try to elucidate the ever growing question of distinguishing independent primaries from intrapulmonary metastasis. In contrast to some other authors, they conclude that mutational analysis is not sufficient to make this distinction, a conclusion with which I am in complete agreement.
I chose this third article, “A Validation Study for the Use of ROS1 Immunohistochemical Staining in Screening for ROS1 Translocations in Lung Cancer”, as we are tackling with the question of bringing this up in our practice. I look forward to your opinions and what you are doing in your practice.
Finally, Roger will discuss “Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study. Kakinuma”. Although this article has more of a clinical bent, it is a recurring theme in our tumor boards, often with no satisfying answers. And the authors’ conclusions still leave us pondering on how can we predict which SSN nodules will progress and which ones won’t? Is there a predictive biomarker that we have yet to discover that could answer this question?
Good end of summer reading!
1. Could prominent airway-centered fibroblast foci in lung biopsies predict underlying chronic microaspiration in idiopathic pulmonary fibrosis patients? Bois et al. Human Pathol 2016; 53:1
2. Morphological and molecular approach to synchronous non-small cell lung carcinomas: impact on staging. Schneider et al. Mod Pathol 2016; 29:735
3. A Validation Study for the Use of ROS1 Immunohistochemical Staining in Screening for ROS1 Translocations in Lung Cancer. Viola et al. JTO 2016; 11:1029
4. Natural History of Pulmonary Subsolid Nodules: A Prospective Multicenter Study. Kakinuma et al. JTO 2016; 11:1012
Articles for discussion/notation
1. Allergen-induced Changes in Bone Marrow and Airway Dendritic Cells in Subjects with Asthma. El-Gammal et al. AJRCCM 2016; 194 (2): 169
2. Napsin A/p40 Antibody Cocktail for Subtyping Non-Small Cell Lung Carcinoma on Cytology and Small Biopsy Specimens. Nishino ell. Cancer Cytopath 2016; p472
3. A proposal for cellularity assessment for EGFR mutational analysis with a correlation with DNA yield and evaluation of the number of sections obtained from cell blocks for immunohistochemistry in non-small cell lung carcinoma. da Cunha Santos et al. JCP 2016; 69:607
4. Prognostic Significance of PD-L1 in Patients with Non–Small Cell Lung Cancer: A Large Cohort Study of Surgically Resected Cases. Sun et al. JTO 2016; 11:1003
Articles for notation
1. Thymomas With Extensive Clear Cell Component. A Clinicopathologic and Immunohistochemical Study of Nine Cases. Weissferdt et al. AJCP 2016; 146:132
2. Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Ho et al. AJCCRM 2016; 194:77. Accompanied by an Editorial.
3. Clinical Validation of a Novel Commercial Reverse Transcription–Quantitative Polymerase Chain Reaction Screening Assay for Detection of ALK Translocations and Amplifications in Non–Small Cell Lung Carcinomas. Liu et al. Arch Pathol Lab Med 2016; 140:690
4. Folate Receptor α Expression Level Correlates With Histologic Grade in Lung Adenocarcinoma. Driver et al. Arch Pathol Lab Med 2016; 140:682
5. Detection of PIK3CA Mutations, Including a Novel Mutation of V344G in Exon 4, in Metastatic Lung Adenocarcinomas: A Retrospective Study of 115 FNA Cases. Allison et al. Cancer Cytopath 2016; p485
6. Epidemiology and survival of idiopathic pulmonary fibrosis from national data in Canada. Hopkins et al. Eur J Respir 2016; 48:26
7. Incidence and prevalence of idiopathic pulmonary fibrosis in US adults 18–64 years old. Raghu1 et al. Eur J Respir 2016; 48: 179
8. Transbronchial needle aspiration in peripheral pulmonary lesions: a systematic review and meta-analysis. Mondoni et al. Eur J Respir 2016; 48:196
9. Double staining of bacilli and antigen Ag85B improves the accuracy of the pathological diagnosis of pulmonary tuberculosis. Che et al. J Clin Pathol 2016; 69:600
10. Prognosis in Resected Invasive Mucinous Adenocarcinomas of the Lung: Related Factors and Comparison with Resected Nonmucinous Adenocarcinomas. Lee et al. JTO 2016; 11:1064
11. High prevalence of ALK+/ROS1+ cases in pulmonary adenocarcinoma of adolescents and young adults. Scarpino et al. Lung Cancer 2016; 97:95
12. Clinicopathological and prognostic significance of programmed cell death ligand-1 expression in lung adenocarcinoma and its relationship with p53 status. Cha et al. Lung Cancer 2016; 97:73
13. MiR-145 and miR-203 represses TGF- β-induced epithelial-mesenchymal transition and invasion by inhibiting SMAD3 in non-small cell lung cancer cells. Hu et al. Lung cancer 2016; 97:87
14. Primary pulmonary clear cell sarcoma—the first two reported cases. Goh et al. Virchows Arch 2016; 469:111
Review articles or consensus statements
1. PD-L1 Expression in Lung Cancer. Yu et al. JTO 2016; 11:964
2. Transthoracic Needle Aspiration Biopsy for the Cytologic Diagnosis of Subsolid Lung Nodules. Klein. Cancer Cytopath 2016; p451
3. Predictive Markers for the Efficacy of Anti–PD-1/PD-L1 Antibodies in Lung Cancer. Shukuya and Carbone. JTO 2016; 11:976
1. TPD52L1-ROS1, a new ROS1 fusion variant in lung adenosquamous cell carcinoma identified by comprehensive genomic profiling. Zhu et al. Lung Cancer 2016; 97:48