Welcome to the November 2016 edition of Pulmonary Pathology Reviews, a multi-institutional
journal club intended to keep all of us up-to-date when it comes to the fast paced world of the peer reviewed literature relevant to those with an interest in diagnostic thoracic pathology. Today's version comes to us courtesy of Henry Tazelaar at sunny Mayo Clinic Arizona. What follows is his high level OVERVIEW highlighting what's hot and what's not, followed by an ARTICLE INDEX with links to PubMed abstracts. Click here if you want to download his PDF summary of the articles which just might save you the time and trouble of having to read them yourselves. And if you really want to hear how it all went down click here to download an MP3 audiofile of the teleconference as it unfolded at 07:15 MST on Monday, November 28, 2016.
Hope you all had a great Thanksgiving. I for one am thankful we have this group to help sort through the seemingly ever increasing volume of pulmonary pathology related papers. Some of this month’s papers identified some novel findings and/or hypotheses. Kusko, et al using molecular techniques determined that there were convergent transcriptomic networks in COPD and IPF. The accompanying editorial by Weiss puts these findings into context. I found this way of thinking about disease to be quite fascinating even though I don’t understand it all! The articles and editorial by Eddens and Shah respectively discuss the significance of finding that pneumocystis can drive asthma-like pathology and immunologic responses in mice and humans, another potential role for pneumocystis in human disease.
As is becoming increasingly the case, the molecular genetics and the diagnosis of such abnormalties in patients with lung cancer loomed large this month. These include numerous studies, editorials and reviews on liquid biopsies (Wang S, Crosbie, Reck, Reckamp and Jiang et al). Walsh et al actually take a step back and ask whether molecular pathology testing for lung cancer could be more cost effective than it is, something certainly worth reading and thinking about. Suda et al analyze EGFR aberrations in a case study of the patient who died with widely metastatic lung cancer. One of the more remarkable case reports I have seen in a while. Goto et al analyze the associations between microRNAs and increased AKT number in lung carcinoma (way over my head), while Jiang GY et al explore the significance of coiled-coil domain-containing protein 8 (CCDC8) on the invasiveness and migration of non-small-cell lung cancer cells (hint: the more CCDC8 a tumor has, the better off the patient is)! Naito looks at micro-environmental changes in lung carcinoma as it progresses from AIS to lipidic predominant.
New or novel observations which are more strictly anatomic pathology related were made by Hashimoto et al who describe solitary pulmonary hemangiomas in seven adults, and Kawabata who identifies what I think is fundamentally interstitial organization but for which the authors term “acute ischaemic lung injury”; and a case report by Pokharel et al who describe a sclerosing pneumocytoma with lymph node metastases. Other more anatomically related studies are reported by Ichinose who developed an IHC algorithm for distinguishing primary lung squamous carcinoma for metastatic head and neck carcinomas, and Zakowski who studied the morphologic accuracy of the diagnosis of non-small-cell lung carcinomas in a large cytology study.
Finally, there are several large reviews/reports including the 33rd adult lung and heart-lung transplant report by Yusen, an update from the International Epidemiology of Lung Cancer group by Cheng, a review of the literature on VATS lobectomy by Vannucci, and a review of cystic lung disease by Raoof.
Pleural disease is covered in three articles, one by Churg which presents the dataset for the reporting of malignant mesothelioma, an article by Hida et al on the concomitant use of BAP1 IHC and p16 FISH (results similar to previous studies, that using both is more sensitive for the diagnosis of mesothelioma). Hylebos et al review the genetic landscape of malignant pleural mesotheliomas using “massively parallel sequencing”.
It is probably my age, but it seems as though it was way harder to understand some of these papers than in past years. I guess Colby and Leslie can be thankful that some of this is now behind them. We wish you the BEST! We’re going to miss you more than you know!
Articles for Discussion
Biological network modeling and systems biology to advance our understanding of lung disease. Weiss ST. Am J Respir Crit Care Med. 2016;194(8):920-21.
Integrated genomics reveals convergent transcriptomic networks underlying chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis. Kusko et al. Am J Respir Crit Care Med. 2016;194(8):948-60.
Acute ischaemic lung injury due to pulmonary vascular obstruction. Kawabata et al. Histopathology. 2016;69:647-54.
The Registry of the International Society for Heart and Lung Transplantation: Thirty-third Adult Lung and Heart-Lung Transplant Report – 2016; Focus Theme: Primary Diagnostic Indications for Transplant. Yusen et al. J Heart Lung Transplant. 2016;35(10):1170-84.
Immunohistochemical pattern analysis of squamous cell carcinoma: lung primary and metastatic tumors of head and neck. Ichinose et al. Lung Cancer. 2016;100:96-101.
Morphologic accuracy in differentiating primary lung adenocarcinoma from squamous cell carcinoma in cytology specimens. Zakowski et al. Arch Pathol Lab Med. 2016;140:1116-20.
Solitary pulmonary capillary hemangioma of adult cases: clinicopathologic characteristics as an unrecognized entity. Hashimoto et al. Am J Surg Pathol. 2016;40:1380-89.
Sclerosing pneumocytoma with lymph node metastasis. Pokharel et al. J Thorac Oncol. 2016;11(10):1802-4.
Microenvironmental changes in the progression from adenocarcinoma in situ to minimally invasive adenocarcinoma and invasive lepidic predominant adenocarcinoma of the lung. Naito et al. Lung Cancer. 2016;100:53-62.
Coiled-coil domain-containing protein 8 inhibits the invasiveness and migration of non-small cell lung cancer cells. Jiang et al. Human Pathology. 2016;56:64-73.
MicroRNAs associated with increased AKT gene number in human lung carcinoma. Goto et al. Human Pathology. 2016;56:1-10.
The International Epidemiology of Lung Cancer: latest trends, disparities, and tumor characteristics. Cheng et al. J Thorac Oncol. 2016;11(10):1653-71.
Circulating DNA/Liquid Biopsy Articles
Are liquid biopsies ready for prime time of clinical applications? Wang et al. J Thorac Oncol. 2016;11(10):1606-8.
Circulating tumor cells detected in the tumor-draining pulmonary vein are associated with disease recurrence after surgical resection of NSCLC. Crosbie et al. J Thorac Oncol. 2016;11(10):1793-97.
ctDNA determination of EGFR mutation status in European and Japanese patients with advanced NSCLC: The ASSESS Study. Reck et al. J Thorac Oncol. 2016;11(10):1682-89.
A highly sensitive and quantitative test platform for detection of NSCLC EGFR mutations in urine and plasma. Reckamp et al. J Thorac Oncol. 2016;11(10):1690-700.
The diagnostic value of circulating cell free DNA quantification in non-small cell lung cancer: a systematic review with meta-analysis. Jiang et al. Lung Cancer. 2016;100:63-70.
Heterogeneity of EGFR aberrations and correlation with histologic structures: analyses of therapy-naïve isogenic lung cancer lesions with EGFR mutation. Suda et al. J Thorac Oncol. 2016;11(10):1711-17.
Is VATS lobectomy standard of care for operable non-small cell lung cancer? Vannucci et al. Lung Cancer. 2016;100:114-19.
Could molecular pathology testing in lung cancer be more cost-effective? Walsh et al. J Clin Pathol. 2016;69:938-41.
Dataset for reporting of malignant mesothelioma of the pleura or peritoneum: recommendations from the International Collaboration on Cancer Reporting (ICCR). Churg et al. Arch Pathol Lab Med. 2016;140:1104-10.
BAP1 immunohistochemistry of p16 FISH results in combination provide higher confidence in malignant pleural mesothelioma diagnosis: ROC analysis of the two tests. Hida et al. Pathol Int. 2016;66:563-70.
The genetic landscape of malignant pleural mesothelioma: results from massively parallel sequencing. Hylebos et al. J Thorac Oncol. 2016;11(10):1615-26.
A novel CD4+ T cell-dependent murine model of pneumocystis-driven asthma-like pathology. Eddens et al. Am J Respir Crit Care Med. 2016;194(7):807-20.
Opportunist turns allergen: double life of pneumocystis jirovecii in asthma. Shah et al. Am J Respir Crit Care Med. 2016;194(7):779-93.
Cystic lung diseases: algorithmic approach. Raoof et al. Chest. 2016;150(4):945-65.
Eosinophilic pneumonia associated with pirfenidone therapy. Gomez et al. Eur Respir J. 2016;48:1240-42.