Welcome to another delayed edition of Pulmonary Pathology Reviews, a monthly journal club for which materials are posted here to help others keep pace with peer reviewed publications of potential value to anyone interested in pulmonary pathology. February's journal club came to us courtesy of Jennifer Boland at Mayo Clinic Minnesota, with support/participation of pulmonary pathology fellow, Wadad Mneimneh. Between them they canvassed articles that appeared in print in January and selected those worthy of discussion or notation. What follows is their OVERVIEW highlighting what's hot and what's not, followed by an ARTICLE INDEX with links to PubMed abstracts. Click here for their article synopses in PDF format. And if you want to hear how it all went down on an incredibly chilly Monday morning at 08:15 CST on February 16, 2015 click here to download an MP3 audiofile (be patient - could take a while depending on your bandwidth).
Another busy month in the pulmonary literature! I have selected 2 articles to discuss, and 2 will be discussed by one of our current pulmonary pathology fellows, Dr. Wadad Mneimneh. The first is an article by Messinger et al published in Cancer, describing a very large cohort of pleuropulmonary blastoma patients (350 cases) confirmed by central pathology review by the International Pleuropulmonary Blastoma Registry, including a fairly detailed analysis of clinical and pathologic factors. Next is a study I wish I had been able to perform, published by Anderson et al published in AJSP. They describe 52 patients with thoracic epithelioid vascular tumors. They provide a proposed grading system for these tumors based on outcome (which has been proposed in the soft tissue WHO), and look at the utility of testing for the WWTR1-CAMTA1 fusion gene, which at this point is thought to be specific for epithelioid hemangioendothelioma. In the arena of non-neoplastic lung disease, Wadad will discuss the Chest article by Kim et al, which describes the interstitial lung diseases patterns observed in patients with undifferentiated connective tissue disease, with discussion of the prognosis of various observed patterns compared to the idiopathic interstitial pneumonias. Finally, Wadad covers another Chest article by Tapias et al, which seeks to validate a scoring system to predict recurrence in pleural solitary fibrous tumors.
There were other noteworthy publications in lung cancer research this month, including an interesting clinical look at outcomes of patients with interstitial lung disease who develop lung cancer, and a preoperative risk stratification model for patients undergoing resection of pulmonary metastases from bone and soft tissue sarcomas. The molecular testing research front seems to be cooling off a bit, but there was an interesting article looking an minimum number of tumor cells needed for EGFR testing by Scarpino et al. There were also several interesting articles relevant to mediastinal neoplasms, including a nice study by Roden et al. looking at the utility of Ki67 staining in distinguishing different thymic epithelial neoplasms (type A and B3 thymomas, and thymic carcinomas), and two large retrospective multicenter studies looking at thymic carcinoma and thymic neuroendocrine tumors.
Noteworthy non-neoplastic articles include what I though was a very interesting read by Krexi et al, describing pulmonary vascular hypertensive changes found at autopsy in patients experiencing sudden death, who did not have known pre-mortem signs and symptoms of pulmonary hypertension. There is also a study by DaSilva et al, looking at a large cohort of LAM patients with tuberous sclerosis compared to sporadic LAM, with a close look at severity of lung disease. There are two small studies looking at rare interstitial lung diseases, including pleuropulmonary fibroelastosis and anti-KS transfer RNA synthetase syndrome. There are also several very interesting case reports and small series- diffuse dendritiform pulmonary ossification, pulmonary fibrosis in dyskeratosis congenita, spontaneous regression of NSCLC in AIDS after immune reconstitution, and a sarcomatoid pleural mesothelioma with osteosarcomatous, chondrosarcomatous, and rhabdomyoblastic elements!
Articles for discussion
Anderson et al. Thoracic epithelioid malignant vascular tumors- A clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol; 39: 132-139.
Messinger et al. Pleuropulmonary blastoma: A report on 350 central pathology-confirmed pleuropulmonary blastoma cases by the international pleuropulmonary blastoma registry. Cancer 2015; 121: 276-85.
Kim et al. Interstitial pneumonia related to undifferentiated connective tissue disease- Pathologic pattern and prognosis. Chest 2015; 147(1): 165-172.
Tapias et al. Validation of a scoring system to predict recurrence of resected solitary fibrous tumors of the pleura. Chest 2015; 147(1): 216-223.
Articles for notation
Ahmad et al. Thymic carcinoma outcomes and prognosis: Results of an international analysis. J Thorac Cardiovasc Surg 2015; 149: 95-101.
Bueno et al. Validation of a molecular and pathologic model for five-year mortality risk in patients with early stage adenocarcinoma. J Thorac Oncol 2015; 10: 67-73.
Dorsey et al. Tracking of viable circulating tumor cells (CTCs) in the peripheral blood of non-small cell lung cancer (NSCLC) patients undergoing definitive radiation therapy: Pilot study results. Cancer 2015; 121: 139-149.
Filosso et al. Outcome of primary neuroendocrine tumors of the thymus: A joint analysis of the International Thymic Malignancy Interest Group and the European Society of Thoracic Surgeons databases. J Thorac Cardiovasc Surg 2015; 149(1): 103-109.
Ishikawa et al. Micronodular thymoma with lymphoid stroma: an immunohistochemical study of the distribution of Langerhans cells and mature dendritic cells in 6 patients. Histopathology 2015; 66: 300-307.
Jin et al. ROS1 gene rearrangement and copy number gain in non-small cell lung cancer. Virchows Archives 2015; 466: 45-52.
Lee et al. Reactive oxygen species modulator 1 (Romo1) expression is an independent predictor of poor survival in NSCLC patients who undergo surgical resection. Lung Cancer 2015; 87: 45-52.
Lin et al. Risk stratification of patients undergoing pulmonary metastatectomy for soft tissue and bone sarcomas. J Thorac Cardiovasc Surg 2015; 149(1): 85-92.
Miyahara et al. Clinicopathological analysis of pleomorphic carcinoma of the lung: Diffuse ZEB1 expression predicts poor survival. Lung Cancer 2015; 87: 39-44.
Nakamura et al. Close association of IASLC/ATS/ERS lung adenocarcinoma subtypes with glucose-update in positron emission tomography. Lung Cancer 2015; 87: 28-33.
Roden et al. Diagnostic significance of cell kinetic parameters in World Health Organization Type A and B3 thymomas and thymic carcinomas. Human Pathol 2015; 46: 17-25.
Sato et al. Long-term results and predictors of survival after surgical resection of patients with lung cancer and interstitial lung diseases. J Thorac Cardiovasc Surg 2015; 149: 64-70.
Scarpino et al. EGFR mutation testing in pulmonary adenocarcinoma: Evaluation of tumor cell number and tumor percentage in paraffin sections of 120 small biopsies. Lung Cancer 2015; 87: 8-13.
Stiles et al. Characteristics and outcomes of second nodules identified on initial computed tomography scan for patients undergoing resection for primary non-small cell lung cancer. J Thorac Cardiovasc Surg 2015; 149: 19-24.
Suzuki et al. Her2 gene mutations in non-small cell lung carcinomas: Concurrence with her2 gene amplification and her 2 protein expression and phosphorylation. Lung Cancer 2015; 87: 14-22.
Weiss et al. In the hunt for therapeutic targets: Mimicking the growth, metastasis, and stromal associations of early-stage lung cancer using a novel orthotopic animal model. J Thorac Oncol 2015; 10: 46-58.
DiPianto et al. Heterologous gene expression signatures correspond to distinct lung pathologies and biomarkers of disease severity in idiopathic pulmonary fibrosis. Thorax 2015; 70: 48-56.
Krexi and Sheppard. Pulmonary vascular hypertensive changes in lungs of patients with sudden unexpected death. Emphasis on congenital heart disease, Eisenmenger syndrome, postoperative deaths, and death during pregnancy and postpartum. J Clin Pathol 2015; 68: 18-21.
Rosenbaum et al. Pleuroparenchymal fibroelastosis: a pattern of chronic lung injury. Human Pathol 2015; 46: 137-146.
Schneider et al. The pulmonary histopathology of Anti-KS transfer RNA synthetase syndrome. Arch Pathol Lab Med 2015; 139: 122-125.
Taveira-DaSilva et al. Severity and outcome of cystic lung disease in women with tuberous sclerosis complex. Eur Resp J 2015; 45: 171-180.
Huang et al. Non-coding RNA: A new tool for the diagnosis, prognosis and therapy of small cell lung cancer. J Thorac Oncol 2015; 10: 28-37.
Jiang et al. FGFR1 amplification in lung squamous cell carcinoma: A systematic review with meta-analysis. Lung Cancer 2015; 87: 1-7.
Lakshmanan et al. Mucins in lung cancer- Diagnostic, prognostic, and therapeutic implications. J Thorac Oncol 2015; 10: 19-27.
McAfee et al. Helping smokers quit- Opportunities created by the affordable care act. New Engl J Med 2015; 372(1): 5-7.
Rice et al. Rarest of a rare disease: Challenges in advancing our knowledge of thymic carcinoma. J Thorac Cardiovasc Surg 2015; 149(1): 101-102.
Yamada et al. Pneumocyte injury and ubiquitin-positive pneumocytes in interstitial lung disease. Histopathology 2015; 66:161-172.
Case reports/Letters to the Editor
Bisceglia et al. Diffuse dendritiform pulmonary ossification: Report of 2 cases and review of the literature. Adv Anat Pathol 2015; 22: 59-68.
Dvorak et al. Pulmonary fibrosis in dyskeratosis congenita: Report of 2 cases. Human Pathol 2015; 46: 147-152.
Khawar et al. Pulmonary artery sarcoma: Not every filling defect is a pulmonary thromboembolism. J Thorac Oncol 2015; 10(1): 218-219.
Menon et al. Spontaneous regression of non-small cell lung cancer in AIDS after immune reconstitution. J Thorac Oncol 2015; 10(1): e1-2.
Piciucchi et al. A case of amiodarone-induced acute fibrinous and organizing pneumonia mimicking mesothelioma. Am J Resp Crit Care Med 2015; 191: 104-6.
Porzionato et al. Diffuse pulmonary ossification in permanent vegetative state. Pathol International 2015; 65: 27-32.
Ricordel et al. EGFR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: Report of two cases and review of the literature. Lung Cancer 2015; 87: 80-84.
Rusch et al. Prevalence of BRCA-associated protein 1 germline mutations in sporadic pleural malignant mesothelioma cases. Lung Cancer 2015; 87: 77-79.
Sogaared et al. Sarcoidosis and subsequent cancer risk: A Danish nationwide cohort study. Eur Resp J 2015; 45: 269-272.
Tsukamoto et al. Sarcomatoid pleural mesothelioma with osteosarcomatous, chondrosarcomatous, and rhabdomyoblastic elements: An extremely rare autopsy case. Pathol International 2015; 65: 51-53.