Fell behind this month in creating this post for our April 2015 edition of Pulmonary Pathology Reviews which actually occurred on Monday morning, May 4th, at 08:15 CDT courtesy of Joanne (Eunhee) Yi and pulmonary pathology fellow, Scott Aesif, at Mayo Clinic Minnesota. What follows is their OVERVIEW summarizing the highs and the lows for peer-reviewed literature that hit print media in March. The OVERVIEW is followed by an ARTICLE INDEX with links to PubMed abstracts and full text versions for Discussion articles if your institution allows access. Click here if you want her PDF summary of not only the articles reviewed but also those reserved for notation only. Click here if you want to download an MP3 audiofile of the unedited and unfiltered teleconference as it occurred nearly two weeks ago. But beware . . . may take awhile to download depending on your bandwidth and you may not always like what you hear whatever your internet speed!
There were almost too many interesting articles, after a bit of drought last month, and I had to be choosy to select 32 papers to review. Although there are still more papers on neoplastic than non-neoplastic diseases, I found a few interesting non-neoplastic papers including the two related to pleuropulmonary fibroelastosis (PPFE), both of which will be discussed as Discussion articles. I realized that I included more clinically or epidemiologically oriented papers for Discussion this month and hope that will work.
Steuer et al looked into epidemiology of atypical carcinoid (AC) using SEER database for more comprehensive snapshot of AC. Arguably, AC is a kind of neglected category of which we might have a skewed view; most clinical information on AC tends to be from surgical series and thus might have given us the picture from more early stage diseases, for example. They used this NIH sponsored SEER database from 18 population-based cancer registries and tried.
Nunes et al. delved into survival in idiopathic NSIP patients by picking up undifferentiated connective tissue disease (UCTD) patients who might have compromised the prognosis of “idiopathic” NSIP patients. The same group of authors published a paper entitled “Prognostic relevance of histological variants in NSIP” using this cohort last year (Histopathology 2014;65:649-60); this previous paper was focused on the different histopathologic findings in NSIP that would suggest different underlying conditions.
Hirota et al and Takeuchi et al, both from Japan, reported PPFE cases from different aspects. Hirota’s paper looked at 4 patients who they claimed showed that they develop PPFE from what looked like acute lung injury. Takeuchi’s paper reported the case series of PPFE as sequelae of hematopoietic stem cell transplantation.
Jiang et al did a meta-analysis and found that multiple primary lung cancers (either metachronous or synchronous) had better overall survival than those with intrapulmonary metastasis, which is not surprising. However, the criteria to determine the same (i.e. metastasis) vs. separate primary (i.e. multiple lung cancers) would be in question; Dr. Aubry et al at Mayo Clinic has been studying on this for the last few years using mate-pair molecular analysis to determine the same vs. different tumors.
The mystery of underlying etiology or pathogenesis of familial pulmonary interstitial fibrosis has been unraveled and one of the progresses has been made by population based genetic survey. Cogan and his multi-institutional collaborators found that RTEL1, the latest regulator found in telomerase gene, plays a role in pulmonary fibrosis that runs in some unfortunate families. An ambitious project to find autoimmune antigen(s) related to sarcoidosis has been carried out by Haggmark et al via proteomic screening approach. A new antibody aPEP13h, though not commercially available yet, has been reported to be much more sensitive in LAM cells than the lame HMB45 antibody that is not very sensitive as you all probably noted. Our pulmonary journal club members Drs. Aubry and Boland published nice and very informative papers on the genetic abnormalities of TP63 gene in pulmonary adenocarcinomas and thoracic MPNSTs, respectively that are definitely worth your attention and reading. There are a couple of papers on PD-L1 expression on small cell lung cancers and thymic epithelial tumors, using very different criteria for positivity and data analysis, which highlights the issue of heterogeneity leading to a serious confusion.
There are many other papers of note and I hope you enjoy reading!
Articles for discussion
Steuer et al. Atypical carcinoid tumor of the lung. A surveillance, epidemiology, and end results database analysis. J Thorac Oncol 2015;10:479-85
Nunes et al. Nonspecific interstitial pneumonia: Survival is influenced by the underlying cause. Eur Respir J 2015;45:746-55
Hirota et al. Histological evolution of pleuroparenchymal fibroelastosis. Histopathology 2015;66:545-554
Takeuchi et al. Pleuroparenchymal fibroelastosis and non-specific interstitial pneumonia: frequent pulmonary sequelae of haematopoietic stem cell transplantation. Histopathology 2015;66:536-44
Jiang et al. Prognosis of synchronous and metachronous multiple primary lung cancers: Systemic review and meta-analysis. Lung Cancer 2015; 87:303-10
Articles for notation
Stanley et al. What the genetics “RTEL”ing us about telomeres and pulmonary fibrosis. Am J Respir Crit Care Med 2015;191(6):608-610
(Editorial for Cogan et al below)
Cogan et al. Rare variants in RTEL1 are associated with familial interstitial pneumonia. Am J Respir Crit Care Med 2015;191:646-655
Haggmark et al. Proteomic profiling reveals autoimmune targets in sarcoidosis. Am J Respir Crit Care Med 2015;191(5):574-583
Shoemark et al. Bardet Biedl Syndrome motile ciliary phenotype. Chest 2015;147(3):764-770
van den Kieboom et al. Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection. Eur Respir J 2015;45:718-725
Valencia et al. Antibody αPEP13h reacts with lymphangioleiomyomatosis cells in lung nodules. Chest 2015;147(3):771-777
Aubry et al. Chromosomal rearrangements and copy number abnormalities of TP63 correlate with p63 protein expression in lung adenocarcinoma. Mod Path 2015;28:359-366
Boland et al. Intrathoracic peripheral nerve sheath tumors – a clinicopathological study of 75 cases. Hum Path 2015;46:419-425
Weissferdt et al. Primary mediastinal seminomas: a comprehensive immunohistochemical study with a focus on novel markers. Hum Path 2015;46:376-383
Ishii et al. Significance of programmed cell death-ligand 1 expression and its association with survival in patients with small cell lung cancer. J of Thorac Oncol 2015;10(3):426-430
Padda et al. Diffuse high intensity PD-L1 staining in thymic epithelial tumors. J Thorac Oncol 2015;10(3):500-508
Carbone et al. Recent insights emerging from malignant mesothelioma genome sequencing. J Thorac Oncol 2015;10(3):409-411
Iacono et al. Targeted next-generation sequencing of cancer genes in advanced stage malignant pleural mesothelioma. J Thorac Oncol 2015;10(3):492-499
Patnaik et al. MiR-205 and MiR-375 microRNA assays to distinguish squamous cell carcinoma from adenocarcinoma in lung cancer biopsies. J Thorac Oncol 2015;10(3):446-453
Akaike et al. Distinct clinicopathological features of NAB2-STAT6 fusion gene variants in solitary fibrous tumor with emphasis on the acquisition of highly malignant potential. Hum Path 2015;46:347-356
Yatabe et al. EGFR mutation testing practices within the Asia Pacific region. J Thorac Oncol 2015;10(3):438-445
Yu et al. Prognostic impact of KRAS mutation subtypes in 677 patients with metastatic lung adenocarcinomas. J Thorac Oncol 2015;10(3):431-437
Hu et al. Aspiration-related pulmonary syndromes. Chest 2015;147(3):815-823
Weibel. On the tricks alveolar epithelial cells play to make a good lung. Am J Respir Crit Care Med 2015;191(5):504-513
Meiners et al. Hallmarks of the ageing lung. Eur Respir J 2015;45:807-827
Rossi et al. Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing. Eur Respir J 2015;45:774-789
Reilly et al. Linking genetics to ARDS pathogenesis. The role of the platelet. Chest 2015;147(3):585-586
Kosmidis et al. The clinical spectrum of pulmonary aspergillosis. Thorax 2015;70:270-277
Iacono et al. Future options for ALK-positive non-small cell lung cancer. Lung Cancer 2015;87:211-219
Pelosi et al. Large cell carcinoma of the lung: A tumor in search of an author. A clinically oriented critical reappraisal. Lung Cancer 2015;87:226-231
Byers et al. Small cell lung cancer: Where do we go from here? Cancer 2015;121:664-72
Robesova et al. Identification of atypical ATRN1 insertion to EML4-ALK fusion gene in NSCLC. Lung Cancer 2015;87:318-20